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Influence of Histaminergic Cerebellar System in Motor Learning and Emotional Memory in Mice

Grant number: 16/00557-3
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): November 01, 2016
Effective date (End): August 25, 2020
Field of knowledge:Humanities - Psychology - Physiological Psychology
Principal researcher:Rosana Mattioli
Grantee:Bruna Silva Marques
Home Institution: Centro de Ciências Biológicas e da Saúde (CCBS). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil
Associated scholarship(s):18/08099-0 - Carbonic Anhydrase Activation in the Extinction of Fear Conditioning in Rats, BE.EP.DR

Abstract

Experimental evidence indicates that the cerebellum is involved in motor and non-motor functions. Since our recent results have demonstrated the participation of the cerebellar histaminergic system in the consolidation of emotional memory, this study aims to investigate the role of the histaminergic neural system in motor learning of mice via cerebellar vermis and establish a possible interaction of this system in processing motor and non-motor function. Will be conducted four experiments to investigate the dose-dependent effects of histamine microinjected in the cerebellar vermis; the effects of microinjection of H1 receptor antagonist (chlorpheniramine); the effects of microinjection of H2 receptor antagonist (ranitidine) and; Microinjection the effects of H3 receptor antagonist (thioperamide) on anxiety, motor performance and learning motor mice. For it will be used the elevated plus maze, rota-rod and balance beam. Statistical analysis include the homogeneity test and analysis of variance (ANOVA) followed by post-hoc test to the appropriate experimental design. The Pearson correlation coefficient is used to verify the correlation between the motor and emotional learning.

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