Characterization of inflammatory profile in obese animals by high-fat diet

• Grant number: 10/50156-9
• Support Opportunities: Regular Research Grants
• Start date: July 01, 2010
• End date: June 30, 2012
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Antonio Carlos Cicogna
• Grantee: Antonio Carlos Cicogna
• Host Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

Currently the inflammation has been defined as a defense mechanism of the tissue in response to an attack. The inflammatory response is triggered by chemical mediators that are responsible for the attempt to destroy the offending agent and repair tissue damage. Cytokines may perform anti and pro-inflammatory and secreted mainly by adipose tissue and immune cells, vascular and stroma Research shows that elevations of several proinflammatory cytokines produce inflammation and are determinates of various cardiovascular disorders. The pro-inflammatory adipokines affect the process of myocardial remodeling by influencing aspects such as hypertrophy, apoptosis, fibrosis and contractility. The levels of adipokines are related with the amount of adipose tissue. Studies show that obesity has often been associated with increased pro-inflammatory markers and decrease of anti-inflammatory. Research currently conducted in our laboratory using animals for obese fat diet for 15 weeks and observed functional impairment, decreased phosphorylation of phospholamban (Ser16) and least amount of myocardial interstitial collagen. However, these authors did not assess whether these changes could be related to variations in levels of adipokines pro and anti-inflammatory. Therefore, the purpose of this study is to characterize the inflammatory status in obese animals for 15 weeks. Our hypothesis is that obesity will lead to increased pro-inflammatory adipokines, with consequent reduction of anti-inflammatory. (AU)