Strength training with vascular occlusion: hormonal, morphological and molecular changes

• Grant number: 09/09820-5
• Support Opportunities: Regular Research Grants
• Start date: December 01, 2009
• End date: November 30, 2010
• Field of knowledge: Health Sciences - Physical Education
• Principal Investigator: Valmor Alberto Augusto Tricoli
• Grantee: Valmor Alberto Augusto Tricoli
• Host Institution: Escola de Educação Física e Esporte (EEFE). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Strength training (ST) combined with vascular occlusion (STVO) has been proposed as a new paradigm to improve strength and increase in muscle mass. Recent studies have shown that low intensity (20-50% 1RM) STVO results similar hypertrophy and enhancement in strength performance when compared to high intensity (80% 1RM) ST. However, the mechanisms behind such effects are still unclear. One possible explanation is the elevation in plasma concentration of growth hormone, testosterone, IGF-1 and cortisol due to the hypoxic condition caused by vascular occlusion. The first three hormones contribute to protein synthesis. Nevertheless, increases in muscle mass are determined by a balance between protein synthesis and degradation. Thus, not only stimulation of synthesis pathways but a greater inhibition of degradation pathways are important to increase muscle mass. Myostatin is a muscle mass down regulator and up to date the effects of STVO on its activity are unknown. Therefore, the objective of this study will be to investigate functional and morphological adaptations, changes in hormonal plasma concentration and changes in myostatin gene expression due to 8 weeks of ST and STOV. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

LAURENTINO, GILBERTO CANDIDO; UGRINOWITSCH, CARLOS; ROSCHEL, HAMILTON; AOKI, MARCELO SALDANHA; SOARES, ANTONIO GARCIA; NEVES, JR., MANOEL; AIHARA, ANDRE YUI; CORREA FERNANDES, ARTUR DA ROCHA; TRICOLI, VALMOR. Strength Training with Blood Flow Restriction Diminishes Myostatin Gene Expression. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, v. 44, n. 3, p. 406-412, MAR 2012. (09/09820-5)

FERNANDES, RODRIGO VOLGA; TRICOLI, VALMOR; SOARES, ANTONIO GARCIA; MIYABARA, ELEN HARUKA; AOKI, MARCELO SALDANHA; LAURENTINO, GILBERTO. Low-Load Resistance Exercise with Blood Flow Restriction Increases Hypoxia-Induced Angiogenic Genes Expression. Journal of Human Kinetics, v. 84, n. 1, p. 10-pg., 2022-11-08. (09/09820-5)

LAURENTINO, GILBERTO C.; LOENNEKE, JEREMY P.; UGRINOWITSCH, CARLOS; AOKI, MARCELO S.; SOARES, ANTONIO G.; ROSCHEL, HAMILTON; TRICOLI, VALMOR. Blood-Flow-Restriction-Training-Induced Hormonal Response is not Associated with Gains in Muscle Size and Strength. Journal of Human Kinetics, v. 83, n. 1, p. 9-pg., 2022-09-08. (09/09820-5)