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Generation of human artificial skins and invasive melanomas as a platform for pharmacological testing

Grant number: 08/58817-4
Support Opportunities:Regular Research Grants
Duration: April 01, 2009 - June 30, 2011
Field of knowledge:Biological Sciences - Biochemistry - Molecular Biology
Principal Investigator:Silvya Stuchi Maria-Engler
Grantee:Silvya Stuchi Maria-Engler
Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Articles published in Pesquisa FAPESP Magazine about the research grant:
Piel de laboratorio 
Laboratory Skin 
Recreated skin 
Articles published in Agência FAPESP Newsletter about the research grant:
Articles published in other media outlets (0 total):
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Scientific publications (8)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FAIAO-FLORES, FERNANDA; PINTO COELHO, PAULO ROGERIO; TOLEDO ARRUDA-NETO, JOAO DIAS; PIRES CAMILLO, MARIA APARECIDA; MARIA-ENGLER, SILVYA STUCHI; GRASSI RICI, ROSE ELI; SOUZA SARKIS, JORGE EDUARDO; MARIA, DURVANEI AUGUSTO. Boron uptake in normal melanocytes and melanoma cells and boron biodistribution study in mice bearing B16F10 melanoma for boron neutron capture therapy. RADIATION AND ENVIRONMENTAL BIOPHYSICS, v. 51, n. 3, p. 319-329, . (08/58817-4)
BROHEM, CARLA A.; MASSARO, RENATO R.; TIAGO, MANOELA; MARINHO, CAMILA E.; JASIULIONIS, MIRIAM G.; DE ALMEIDA, REBECA L.; RIVELLI, DIOGO P.; ALBUQUERQUE, RENATA C.; DE OLIVEIRA, TIAGO F.; DE MELO LOUREIRO, ANA P.; et al. Proteasome inhibition and ROS generation by 4-nerolidylcatechol induces melanoma cell death. PIGMENT CELL & MELANOMA RESEARCH, v. 25, n. 3, p. 354-369, . (08/58817-4, 06/50479-7, 09/54816-6)
DA SILVA CARDEAL, LAURA BEATRIZ; BOCCARDO, ENRIQUE; TERMINI, LARA; RABACHINI, TATIANA; ANDREOLI, MARIA ANTONIETA; DI LORETO, CELSO; LONGATTO FILHO, ADHEMAR; VILLA, LUISA LINA; MARIA-ENGLER, SILVYA STUCHI. HPV16 Oncoproteins Induce MMPs/RECK-TIMP-2 Imbalance in Primary Keratinocytes: Possible Implications in Cervical Carcinogenesis. PLoS One, v. 7, n. 3, . (08/58817-4, 08/03232-1)
BROHEM, CARLA A.; DA SILVA CARDEAL, LAURA B.; TIAGO, MANOELA; SOENGAS, MARIA S.; DE MORAES BARROS, SILVIA B.; MARIA-ENGLER, SILVYA S.. Artificial skin in perspective: concepts and applications. PIGMENT CELL & MELANOMA RESEARCH, v. 24, n. 1, p. 35-50, . (08/58817-4, 06/50479-7)
RENATO RAMOS MASSARO; CARLA ABDO BROHEM; REBECA LEITE DE ALMEIDA; DIOGO PINEDA RIVELLI; JULIANO ANDREOLI MIYAKE; ALISON COLQUHOUN; SILVIA BERLANGA DE MORAES BARROS; SILVYA STUCHI MARIA-ENGLER. 4-Nerolidylcatechol induces autophagy in human glioblastoma cells. Brazilian Journal of Pharmaceutical Sciences, v. 53, n. 3, . (08/58817-4)
MATHEUS, ERIKA R.; ZONTA, MARCO A.; DISCACCIATI, MICHELLE G.; PARUCI, PRISCILA; VELAME, FERNANDA; CARDEAL, LAURA B. S.; BARROS, SILVIA B. M.; PIGNATARI, ANTONIO C.; MARIA-ENGLER, SILVYA S.. MMP-9 Expression Increases According to the Grade of Squamous Intraepithelial Lesion in Cervical Smears. DIAGNOSTIC CYTOPATHOLOGY, v. 42, n. 10, p. 827-833, . (08/58817-4, 12/09746-2)
FAIAO-FLORES, FERNANDA; QUINCOCES SUAREZ, JOSE AGUSTIN; MARIA-ENGLER, SILVYA STUCHI; SOTO-CERRATO, VANESSA; PEREZ-TOMAS, RICARDO; MARIA, DURVANEI AUGUSTO. The curcumin analog DM-1 induces apoptotic cell death in melanoma. TUMOR BIOLOGY, v. 34, n. 2, p. 1119-1129, . (08/58817-4, 11/50435-8)
FAIAO-FLORES, FERNANDA; PINTO COELHO, PAULO ROGERIO; TOLEDO ARRUDA-NETO, JOAO DIAS; MARIA-ENGLER, SILVYA STUCHI; TIAGO, MANOELA; CAPELOZZI, VERA LUIZA; GIORGI, RICARDO RODRIGUES; MARIA, DURVANEI AUGUSTO. Apoptosis through Bcl-2/Bax and Cleaved Caspase Up-Regulation in Melanoma Treated by Boron Neutron Capture Therapy. PLoS One, v. 8, n. 3, . (08/58817-4)

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