Study of the involvement of cholinergic pathways form tegmentar pedunculopontine nucleus to monoaminergic nuclei of the pain endogenous inhibitory system in the post-ictal antinociception

• Grant number: 09/00668-6
• Support Opportunities: Regular Research Grants
• Start date: November 01, 2009
• End date: October 31, 2011
• Field of knowledge: Biological Sciences - Morphology - Anatomy
• Principal Investigator: Norberto Cysne Coimbra
• Grantee: Norberto Cysne Coimbra
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

It has been reported in Medical Clinics that some patients report oscillations in the nociceptive threshold, a post-seizure phenomenon not yet widely investigated in Neuroscience field. Considering that some antiepileptic medicines cause analgesia as side effects, and taking in mind that the majority of epileptic patients is commonly treated since the first diagnose of epilepsy was made, this fact is a constant problem in the study of that post-ictal phenomenon. The aim of the present project is to investigate the muscarinic and nicotinic cholinergic neurotransmission in the post-ictal antinociception, specifically studying the role of some cholinergic output from the tegmentar pedunculopontine nucleus on serotonergic and noradrenergic neurons of some nuclei of the pain endogenous inhibitory system, such as the raphe magnus nucleus, dorsal raphe nucleus and locus coeruleus, in an experimental model of epilepsy in Rattus norvegicus (Rodentia, Muridae). (AU)

Scientific publications

(12)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DE FREITAS, RENATO LEONARDO; MEDEIROS, PRISCILA; KHAN, ASMAT ULLAH; COIMBRA, NORBERTO CYSNE. mu(1)-Opioid receptors in the dorsomedial and ventrolateral columns of the periaqueductal grey matter are critical for the enhancement of post-ictal antinociception. Synapse, v. 70, n. 12, p. 519-530, DEC 2016. (14/11869-0, 12/25167-2, 13/12916-0, 09/00668-6, 09/17258-5)

DE FREITAS, RENATO LEONARDO; MEDEIROS, PRISCILA; DA SILVA, JULIANA ALMEIDA; DE OLIVEIRA, RITHIELE CRISTINA; DE OLIVEIRA, RICARDO; ULLAH, FARHAD; KHAN, ASMAT ULLAH; COIMBRA, NORBERTO CYSNE. THE mu(1)-OPIOID RECEPTOR AND 5-HT2A- AND 5HT(2C)-SEROTONERGIC RECEPTORS OF THE LOCUS COERULEUS ARE CRITICAL IN ELABORATING HYPOALGESIA INDUCED BY TONIC AND TONIC-CLONIC SEIZURES. Neuroscience, v. 336, p. 133-145, NOV 12 2016. (14/11869-0, 09/02458-9, 11/09850-1, 12/25167-2, 13/12916-0, 09/00668-6, 09/17258-5, 15/10313-1)

BASSI, GABRIEL S.; KANASHIRO, ALEXANDRE; SANTIN, FRANCELE M.; DE SOUZA, GLORIA E. P.; NOBRE, MANOEL J.; COIMBRA, NORBERTO C.. Lipopolysaccharide-Induced Sickness Behaviour Evaluated in Different Models of Anxiety and Innate Fear in Rats. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, v. 110, n. 4, p. 359-369, APR 2012. (09/00668-6)

DE OLIVEIRA, RITHIELE CRISTINA; DE OLIVEIRA, RICARDO; FALCONI-SOBRINHO, LUIZ LUCIANO; BIAGIONI, AUDREY FRANCESCHI; ALMADA, RAFAEL CARVALHO; DOS ANJOS-GARCIA, TAYLLON; BAZAGLIA-DE-SOUSA, GUILHERME; KHAN, ASMAT ULLAH; COIMBRA, NORBERTO CYSNE. Neurotoxic lesions of the pedunculopontine tegmental nucleus impair the elaboration of postictal antinociception. Physiology & Behavior, v. 194, p. 162-169, OCT 1 2018. (11/09850-1, 14/10742-7, 08/08955-1, 09/00668-6, 13/10984-8, 12/22681-7)

DE OLIVEIRA, RITHIELE CRISTINA; DE OLIVEIRA, RICARDO; BIAGIONI, AUDREY FRANCESCHI; FALCONI-SOBRINHO, LUIZ LUCIANO; DOS ANJOS-GARCIA, TAYLLON; COIMBRA, NORBERTO CYSNE. Nicotinic and muscarinic cholinergic receptors are recruited by acetylcholine-mediated neurotransmission within the locus coeruleus during the organisation of post-ictal antinociception. Brain Research Bulletin, v. 127, p. 74-83, OCT 2016. (09/00668-6)

DE FREITAS, RENATO LEONARDO; DE OLIVEIRA, RITHIELE CRISTINA; DE OLIVEIRA, RICARDO; PASCHOALIN-MAURIN, TATIANA; DE AGUIAR CORREA, FERNANDO MORGAN; COIMBRA, NORBERTO CYSNE. The Role of Dorsomedial and Ventrolateral Columns of the Periaqueductal Gray Matter and In Situ 5-HT2A and 5-HT2C Serotonergic Receptors in Post-Ictal Antinociception. Synapse, v. 68, n. 1, p. 16-30, JAN 2014. (09/00668-6)

FELIPPOTTI, TATIANA TOCCHINI; DE FREITAS, RENATO LEONARDO; COIMBRA, NORBERTO CYSNE. Endogenous opioid peptide-mediated neurotransmission in central and pericentral nuclei of the inferior colliculus recruits mu(1)-opioid receptor to modulate post-ictal antinociception. Neuropeptides, v. 46, n. 1, p. 39-47, FEB 2012. (09/00668-6, 09/17258-5)

DE OLIVEIRA, RITHIELE CRISTINA; DE OLIVEIRA, RICARDO; BIAGIONI, AUDREY FRANCISCO; FALCONI-SOBRINHO, LUIZ LUCIANO; COIMBRA, NORBERTO CYSNE. Dorsal raphe nucleus acetylcholine-mediated neurotransmission modulates post-ictal antinociception: The role of muscarinic and nicotinic cholinergic receptors. Brain Research, v. 1631, p. 80-91, JAN 15 2016. (14/10742-7, 08/08955-1, 09/00668-6, 08/09897-5)

DE OLIVEIRA, RITHIELE CRISTINA; DE OLIVEIRA, RICARDO; ZANANDREA, PRISCILA CABRERA; PASCHOALIN-MAURIN, TATIANA; COIMBRA, NORBERTO CYSNE. Acetylcholine-mediated neurotransmission within the nucleus raphe magnus exerts a key role in the organization of both interictal and postictal antinociception. Epilepsy & Behavior, v. 22, n. 2, p. 178-185, OCT 2011. (08/09897-5, 09/00668-6)

FELIPPOTTI, TATIANA TOCCHINI; DO CARMO, DEVANEY RIBEIRO; PAIM, LEONARDO LATARO; STRADIOTTO, NELSON RAMOS; BICALHO, URQUISA DE OLIVEIRA; PARADA, CARLOS AMILCAR; GRILLO, RENATO; FRACETO, LEONARDO FERNANDES; COIMBRA, NORBERTO CYSNE. Effect of a nanostructured dendrimer-naloxonazine complex on endogenous opioid peptides mu(1) receptor-mediated post-ictal antinociception. Nanomedicine-Nanotechnology Biology and Medicine, v. 7, n. 6, p. 871-880, DEC 2011. (09/00668-6)

MAZZEI-SILVA, ELAINE CRISTINA; DE OLIVEIRA, RITHIELE CRISTINA; GARCIA, TAYLLON DOS ANJOS; FALCONI-SOBRINHO, LUIZ LUCIANO; ALMADA, RAFAEL CARVALHO; COIMBRA, NORBERTO CYSNE. Intrinsic Connections within the Pedunculopontine Tegmental Nucleus are Critical to the Elaboration of Post-Ictal Antinociception. Synapse, v. 68, n. 8, p. 369-377, AUG 2014. (09/00668-6)

CARDOSO, FABRIZIO DOS SANTOS; GONZALEZ-LIMA, FRANCISCO; COIMBRA, NORBERTO CYSNE. Mitochondrial Photobiomodulation as a Neurotherapeutic Strategy for Epilepsy. FRONTIERS IN NEUROLOGY, v. 13, p. 5-pg., 2022-06-16. (21/06473-4, 09/00668-6)