New therapeutic targets: the use of recombinant enzymes for screening of drugs for human and veterinary medical interest.

• Grant number: 09/08715-3
• Support Opportunities: Regular Research Grants
• Start date: November 01, 2009
• End date: October 31, 2011
• Field of knowledge: Biological Sciences - Pharmacology - Biochemical and Molecular Pharmacology
• Principal Investigator: Edson Roberto da Silva
• Grantee: Edson Roberto da Silva
• Host Institution: Faculdade de Zootecnia e Engenharia de Alimentos (FZEA). Universidade de São Paulo (USP). Pirassununga , SP, Brazil

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CRUZ, EBENEZER DE MELLO; DA SILVA, EDSON ROBERTO; MAQUIAVELI, CLAUDIA DO CARMO; SOBRAL ALVES, ELIOMARA SOUSA; LUCON, JR., JOAO FRANCISCO; GONCALVES DOS REIS, MATHEUS BALDUINO; MENDES DE TOLEDO, CLEYTON EDUARDO; CRUZ, FREDERICO GUARE; VANNIER-SANTOS, MARCOS ANDRE. Leishmanicidal activity of Cecropia pachystachya flavonoids: Arginase inhibition and altered mitochondrial DNA arrangement. Phytochemistry, v. 89, p. 71-77, MAY 2013. (09/08715-3)

MANJOLIN, LETICIA CORREA; GONCALVES DOS REIS, MATHEUS BALDUINO; MAQUIAVELI, CLAUDIA DO CARMO; SANTOS-FILHO, OSVALDO ANDRADE; DA SILVA, EDSON ROBERTO. Dietary flavonoids fisetin, luteolin and their derived compounds inhibit arginase, a central enzyme in Leishmania (Leishmania) amazonensis infection. Food Chemistry, v. 141, n. 3, p. 2253-2262, DEC 1 2013. (09/08715-3, 12/17059-5)