Polymorphisms in genes related to intracellular protein synthesis and degradation, and their relationships with residual feed intake in Nellore cattle

• Grant number: 08/11363-9
• Support Opportunities: Regular Research Grants
• Start date: May 01, 2009
• End date: April 30, 2011
• Field of knowledge: Agronomical Sciences - Animal Husbandry - Genetics and Improvement of Domestic Animals
• Principal Investigator: José Bento Sterman Ferraz
• Grantee: José Bento Sterman Ferraz
• Host Institution: Faculdade de Zootecnia e Engenharia de Alimentos (FZEA). Universidade de São Paulo (USP). Pirassununga , SP, Brazil

Abstract

Residual feed intake (RFI) has been the prefered method to measure feed efficiency in beef cattle because it is irrespetive of variation in mature weight and growth rate. Because measuring RFI is expensive and laborious, marker-assisted selection may be employed as an additional tool to identify more efficient cattle. However, there is a lack of investigations evaluating associations between molecular markers and RFI in zebu cattle. Polymorphisms in genes that regulate intracellular protein metabolism are candidate markers for this trait. In this way, this study will aim to evaluate associations between RFI and polymorphisms in genes related to protein degradation and synthesis in Nellore cattle. Measuremments of feed intake, weight gain, feed conversion, partial efficiency of growth and residual feed intake will be obtained of about 400 Nellore steers and bulls. Animals will be genotyped for 11 single nucleotide polymorphisms using real time PCR and TaqMan gene expression assays. Estimatives of SNP alelle frequency, heteregosity, additive, dominant and substitution effects and genotypes least square means will be calculated. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

GOMES, R. C.; SILVA, S. L.; CARVALHO, M. E.; REZENDE, F. M.; PINTO, L. F. B.; SANTANA, M. H. A.; STELLA, T. R.; MEIRELLES, F. V.; ROSSI JUNIOR, P.; LEME, P. R.; et al. Protein synthesis and degradation gene SNPs related to feed intake, feed efficiency, growth, and ultrasound carcass traits in Nellore cattle. Genetics and Molecular Research, v. 12, n. 3, p. 2923-2936, 2013. (08/11363-9, 08/10098-0)

ALEXANDRE, PAMELA A.; GOMES, RODRIGO C.; SANTANA, MIGUEL H. A.; SILVA, SAULO L.; LEME, PAULO R.; MUDADU, MAURICIO A.; REGITANO, LUCIANA C. A.; MEIRELLES, FLVIO V.; FERRAZ, JOSE B. S.; FUKUMASU, HEIDGE. Bovine NR1I3 gene polymorphisms and its association with feed efficiency traits in Nellore cattle. META GENE, v. 2, p. 12-pg., 2014-12-01. (08/11363-9, 10/05650-5)