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Effects of moderate intensity chronic physical exercise on the insulin signaling pathways, inflammation and oxidative stress in morbidly obese patients

Grant number: 09/52325-5
Support type:Regular Research Grants
Duration: June 01, 2010 - February 28, 2013
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal researcher:Sarah Monte Alegre
Grantee:Sarah Monte Alegre
Home Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil


The rapid increase in obesity and the consequences for health, including oxidative stress, insulin resistance and other metabolic syndrome related disorders, has led to the development of research on obesity epidemiology, etiology and treatment. Physical exercise is considered an efficient method to reduce metabolic disorders and contribute to weight loss. Low and moderate physical activity is known to increase antioxidant enzyme levels such as glutathione redutase, catalase and superoxide dismutase and glutathione peroxidase. Thus, physical exercise reduces the damage caused by the high concentration of oxidant agents in obese patients. A part from this, aerobic endurance improves insulin sensitivity because of its direct action on insulin pathways and consequently increases skeletic muscle glucose consumption in an insulin independent way possibly connected to AMPK. In addition, through physical exercise, another mechanism related to lipid oxidation can lead to insulin resistance. It follows that knowledge of physiological and molecular mechanisms as a consequence of low and moderate intensity chronic physical activity is very relevant to the understanding of how exercise can be a protection against the damage of excessive weight. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE ALMEIDA, AMANDA ROBERTA; MONTE-ALEGRE, SARAH; ZANINI, MICHELE BIANCA; SOUZA, AGLECIO LUIZ; ETCHEBEHERE, MAURICIO; ROCHA GONTIJO, JOSE ANTONIO. Association between prehypertension, metabolic and inflammatory markers, decreased adiponectin and enhanced insulinemia in obese subjects. NUTRITION & METABOLISM, v. 11, JUN 2 2014. Web of Science Citations: 9.

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