Platelet levels of ADAM10 in tracking Alzheimer's disease: contributions for nursing care

• Grant number: 10/09497-7
• Support type: Regular Research Grants
• Duration: August 01, 2010 - July 31, 2012
• Field of knowledge: Health Sciences - Nursing
• Principal researcher: Sofia Cristina Iost Pavarini
• Grantee: Sofia Cristina Iost Pavarini
• Home Institution: Centro de Ciências Biológicas e da Saúde (CCBS). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil
• Assoc. researchers: Francisco de Assis Carvalho Do Vale ; Heloisa Sobreiro Selistre de Araújo ; Márcia Regina Cominetti ; Patricia Regina Manzine Moralles

Abstract

Alzheimer's disease (AD) is the most common cause of dementia in people over 65 years of age. The Mini Mental State Examination (MMSE) is a brief test of tracking the cognitive deterioration, used internationally and translated into over 50 languages. Studies of laboratory tests of platelet ADAM10 have shown changes in expression in patients with AD. Studies that relate the cognitive symptoms of disease development revealed by neuropsychological tests such as MMSE with molecular biomarkers such as levels of platelet protein ADAM10 may be important for the planning care to the elderly with AD. The aim of this project is to investigate the relationship between the Mini Mental State Examination (MMSE) and the expression of ADAM10 in two groups of elderly people registered (no cognitive change and patients with AD). The subjects will be enrolled in elderly services, reference and counter reference to dementia in the studied city: Units of the Family Health Unit and School Health. This is a descriptive study, based on the assumptions of quantitative research and all care ethics will be observed. Will be apply the individual and household MMSE. The collection of biological material will be made after clinical assessment and diagnosis of the elderly by health professionals of the health unit school. The analysis of biological material will be held at the Laboratory of Biochemistry and molecular biology from the university. After collecting the data, the data will be analyzed using methods of statistical co-relation. The results may contribute to the planning of interventions and implementation of public policies that act in prevention and in care with these populations, especially within the Units of the Family Health Program. (AU)

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FERNANDES MARQUES BIANCO, OTAVIO AUGUSTO; MANZINE, PATRICIA REGINA; CRISPIM NASCIMENTO, CARLA MANUELA; CARVALHO VALE, FRANCISCO ASSIS; IOST PAVARINI, SOFIA CRISTINA; COMINETTI, MARCIA REGINA. Serotoninergic antidepressants positively affect platelet ADAM10 expression in patients with Alzheimer's disease. INTERNATIONAL PSYCHOGERIATRICS, v. 28, n. 6, p. 939-944, JUN 2016. Web of Science Citations: 5.

MANZINE, PATRICIA REGINA; MARCELLO, ELENA; BORRONI, BARBARA; KAMPHUIS, WILLEM; HOL, ELLY; PADOVANI, ALESSANDRO; NASCIMENTO, CARLA CRISPIM; BUENO, PATRICIA DE GODOY; CARVALHO VALE, FRANCISCO ASSIS; PAVARINI, SOFIA CRISTINA LOST; DI LUCA, MONICA; COMINETTI, MARCIA REGINA. ADAM10 gene expression in the blood cells of Alzheimer's disease patients and mild cognitive impairment subjects. BIOMARKERS, v. 20, n. 3, p. 196-201, 2015. Web of Science Citations: 13.

MANZINE, PATRICIA REGINA; BARHAM, ELIZABETH JOAN; CARVALHO VALE, FRANCISCO ASSIS; SELISTRE-DE-ARAUJO, HELOISA SOBREIRO; IOST PAVARINI, SOFIA CRISTINA; COMINETTI, MARCIA REGINA. Platelet a disintegrin and metallopeptidase 10 expression correlates with clock drawing test scores in Alzheimer's disease. INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, v. 29, n. 4, p. 414-420, APR 2014. Web of Science Citations: 13.

MANZINE, PATRICIA REGINA; BARHAM, ELISABETH JOAN; CARVALHO DO VALE, FRANCISCO DE ASSIS; SELISTRE-DE-ARAUJO, HELOISA SOBREIRO; IOST PAVARINI, SOFIA CRISTINA; COMINETTI, MARCIA REGINA. Correlation Between Mini-Mental State Examination and Platelet ADAM10 Expression in Alzheimer's Disease. JOURNAL OF ALZHEIMER'S DISEASE, v. 36, n. 2, p. 253-260, 2013. Web of Science Citations: 12.

MANZINE, PATRICIA REGINA; DE FRANCA BRAM, JESSYKA MARIA; BARHAM, ELISABETH JOAN; CARVALHO DO VALE, FRANCISCO DE ASSIS; SELISTRE-DE-ARAUJO, HELOISA SOBREIRO; COMINETTI, MARCIA REGINA; IOST PAVARINI, SOFIA CRISTINA. ADAM10 as a Biomarker for Alzheimer's Disease: A Study with Brazilian Elderly. DEMENTIA AND GERIATRIC COGNITIVE DISORDERS, v. 35, n. 1-2, p. 58-66, 2013. Web of Science Citations: 18.