Ru(II) complexes with potential chemotherapeutical activities: synthesis, characterization and biological tests

• Grant number: 08/02755-0
• Support Opportunities: Regular Research Grants
• Start date: August 01, 2008
• End date: July 31, 2010
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Inorganic Chemistry
• Principal Investigator: Alzir Azevedo Batista
• Grantee: Alzir Azevedo Batista
• Host Institution: Centro de Ciências Exatas e de Tecnologia (CCET). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil

Abstract

In this project we have as main focus the synthesis of a series of compounds containing a variety of phosphines in their structures, with different basicities, with the objective to evaluate which species of the complexes is really that one that presents antitumoral activity. We do believe that these are the phosphines which are essential part of the complexes and give to them biological activities. In this sense this project has the objective to amplify the number of complexes tested to confirm or not, this suggestion. Thus the complexes by themselves are just to transport the phosphines to the biological targets which are the cancer cells. For sure some specific characteristics of the complexes such as charges and redox potential of the metal center which give to them bigger or smaller hydrophilic or hydrophobic character can influenciate in the antitumoral properties of them. Thus, we have the intention to obtain a variety of complexes containing ligands such as monophosphines, biphosphines, diimines, N-Heterocyclic, carbonyls, tiolates and aminoacids, among others and realize tests of citotoxity in vitro in cells of human tumors, as exemple:MDA-MB-231 and HeLa. Until now we realized tests with complexes containing mainly the dppb [1,4-bis(diphenylphosphino)butane] and 2,2`-bipyridine and complexes containing tiossemicarbazones. In this project we will amplify our work with the dppm [bis(diphenylphosphino)methane]; dppe [1,2-bis(diphenylphosphino)ethane]; dppp [1,3-bis(diphenylphosphino)propane] and dcype [bis-(diciclohexilphosphino)ethane]. The aminoacids to be used in this project are; glycine, DL-alanine; DL-valine; Dl-tyrosine; L-methionine; DL-arginine; DL-lysine; DL-cisteine and triptophane (AU)