Articular sonography of juvenile idiopathic arthritis in remission: a prospective study

• Grant number: 10/50128-5
• Support Opportunities: Regular Research Grants
• Start date: June 01, 2010
• End date: May 31, 2012
• Field of knowledge: Health Sciences - Medicine - Maternal and Child Health
• Principal Investigator: Maria Teresa de Sande e Lemos Ramos Ascensão Terreri
• Grantee: Maria Teresa de Sande e Lemos Ramos Ascensão Terreri
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil

Abstract

Juvenile idiopathic artrhtitis (JIA) is the most common chronic rheumatic disorder of childhood. It has a variable prognosis and is characterized by flares and remissions. The physiopathology of JIA comprises an inflammatory process of the synovium and the periarticular tissues with development of synovial pannus. The synovial pannus is the most pathologic factor of cartilage and bone destruction and can result in joint ankylosis. The improvement of JIA therapy has carried out a better quality of life of patients, decreasing articular damage and increasing clinical remission rates. The preliminary criteria for inactive disease and clinical remission with or without medication are based in clinical and laboratory patterns. Previous studies in JIA that analyzed the knees, hips, interphalangeal joints of the hand and others joints with ultrasound (US) detected subclinical synovitis in patients considered as clinically inactives. It is not clear if subclinical synovitis detected by imaging techniques can predict if assintomatic joints will progress to articular damage and functional worsening. The aims of this study were to evaluate the presence of subclinical synovitis by Doppler US in patients with JIA that are in clinical remission and to determine if there is a correlation between the US findings and clinical, laboratory and functional features of this patients in baseline and at long term. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MIOTTO E SILVA, VANESSA BUGNI; TAVARES DA SILVA, CAROLINA DE FREITAS; VILELA MITRAUD, SONIA DE AGUIAR; VILAR FURTADO, RITA NELY; ESTEVES HILARIO, MARIA ODETE; NATOUR, JAMIL; TERRERI, MARIA TERESA. Do patients with juvenile idiopathic arthritis in remission exhibit active synovitis on joint ultrasound?. RHEUMATOLOGY INTERNATIONAL, v. 34, n. 7, p. 937-945, JUL 2014. (10/50128-5)

MIOTTO E SILVA, VANESSA BUGNI; VILELA MITRAUD, SONIA DE AGUIAR; VILAR FURTADO, RITA NELY; NATOUR, JAMIL; LEN, CLAUDIO ARNALDO; RAMOS ASCENSAO TERRERI, MARIA TERESA DE SANDE E LEMOS. Patients with juvenile idiopathic arthritis in clinical remission with positive power Doppler signal in joint ultrasonography have an increased rate of clinical flare: a prospective study. PEDIATRIC RHEUMATOLOGY, v. 15, NOV 13 2017. (10/50128-5)