Genetic epidemiology in leprosy: association study of 6p21, 17q22, 20p13 and 10p13 candidate regions

• Grant number: 09/16873-8
• Support Opportunities: Regular Research Grants
• Start date: May 01, 2010
• End date: April 30, 2013
• Field of knowledge: Biological Sciences - Genetics - Human and Medical Genetics
• Principal Investigator: Ana Carla Pereira Latini
• Grantee: Ana Carla Pereira Latini
• Host Institution: Instituto Lauro de Souza Lima (ILSL). Coordenadoria de Controle de Doenças (CCD). Secretaria da Saúde (São Paulo - Estado). Bauru , SP, Brazil

Abstract

Brazil is an endemic country for leprosy, which is a disease of skin and peripheral nerves caused by Mycobacterium leprae. Genome-wide scans have identified linkage peaks in the 6p21, 17q22, 20p13 and 10p13 chromosome regions; however, those regions were not systematically investigated in Brazilian population and the results were not replicated in association studies. This study purposes to conduct association analysis for these regions in a family-based design using high-throughput platform genotyping, and to test positive findings in case-control samples from São Paulo and Rio de Janeiro states. Therefore, we intend to produce robust data regarding genetic markers to leprosy susceptibility in our population. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DE SOUZA-SANTANA, FABIANA COVOLO; QUERINO, GISLAINE APARECIDA; CAMARGO, RODRIGO MENDES; BRITO DE SOUZA, VANIA NIETO; BALLALLAI MANGILLI, PRISCILA BETTONI; MIRA, MARCELO TAVORA; BEZERRA, OHANNA CAVALCANTI; KEHDY, FERNANDA; LAGUILA VISENTAINER, JEANE ELIETE; ALVES, HUGO VICENTIN; et al. HLA-DPB1 and HLA-C alleles are associated with leprosy in a Brazilian population. HUMAN IMMUNOLOGY, v. 82, n. 1, p. 11-18, JAN 2021. (09/16873-8)

MEDEIROS, PRISCILA; DA SILVA, WEBER LAURENTINO; DE OLIVEIRA GIMENEZ, BRUNA BEATRIZ; VALLEZI, KEREN BASTOS; MORAES, MILTON OZORIO; BRITO DE SOUZA, VANIA NIETO; PEREIRA LATINI, ANA CARLA. The GATA3 gene is involved in leprosy susceptibility in Brazilian patients. INFECTION GENETICS AND EVOLUTION, v. 39, p. 194-200, APR 2016. (09/16873-8, 14/04143-3)

RODRIGO MENDES DE CAMARGO; WEBER LAURENTINO DA SILVA; PRISCILA MEDEIROS; ANDREA DE FARIA FERNANDES BELONE; ANA CARLA PEREIRA LATINI. Polymorphisms in the TGFB1 and IL2RA genes are associated with clinical forms of leprosy in Brazilian population. Memórias do Instituto Oswaldo Cruz, v. 113, n. 12, 2018-12-10. (09/16873-8)