Gene expression profile in pharmacoresistant epilepsy in children

• Grant number: 07/04538-4
• Support Opportunities: Regular Research Grants
• Start date: January 01, 2008
• End date: June 30, 2010
• Field of knowledge: Health Sciences - Medicine - Surgery
• Principal Investigator: Helio Rubens Machado
• Grantee: Helio Rubens Machado
• Host Institution: Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da USP (HCMRP). Secretaria da Saúde (São Paulo - Estado). Ribeirão Preto , SP, Brazil
• Associated researchers: Beatriz Maria de Carvalho Paixão ; Dimas Tadeu Covas ; Elvis Terci Valera ; Luciano Neder Serafini ; Paulo Peitl Junior ; Ricardo Santos de Oliveira ; Vanessa da Silva Silveira ; Vera Cristina Terra

Abstract

Epilepsy is the most prevalent CNS disease in the world, affecting 1% of general population. In children, epilepsy in frequently associated to brain lesions, both of neoplastic and non-neoplastic etiology, such as disembrioplasic neuroepithelial tumors (DNET) and diffuse cortical dysplasia (DCD) respectively. Epileptic syndromes beginning in childhood may render severe neurological impairments. Researches on animal models have shown alterations in cell expression of different proteins, suggesting alterations on gene expression in this disease. The information related to epilepsy in humans is scarce, particularly in children, and may render substrate to new therapeutical approaches in this field (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

GROTTO, DENISE; VALENTINI, JULIANA; SERPELONI, JULIANA MARA; PONTE MONTEIRO, PATRICIA ALVES; LATORRACA, ELDER FRANCISCO; DE OLIVEIRA, RICARDO SANTOS; GREGGI ANTUNES, LUSANIA MARIA; GARCIA, SOLANGE CRISTINA; BARBOSA, JR., FERNANDO. Evaluation of toxic effects of a diet containing fish contaminated with methylmercury in rats mimicking the exposure in the Amazon riverside population. Environmental Research, v. 111, n. 8, p. 1074-1082, NOV 2011. (09/11102-3, 11/07416-2, 11/07498-9, 07/05221-4, 07/04538-4)