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Cellular mechanism of inactivating tumor by photodynamic therapy


A tumor is characterized by abnormal growth of living tissue and may be benign or malignant. Cancer is known that the disease has caused more apprehension has been provoking in the humanity's history. Until recently, the cancers were defined according to the tumor cell itself, are now seen as more complex diseases involving many different cell types present in the same microenvironment: defense cells, blood vessels and supporting tissue. Given this new knowledge was possible the emergence of other targets for therapies against these evils. As the interactions between these different cells are better understood, it is possible to develop new forms of treatment. As a result, alternative treatments have been developed, among which include Photodynamic Therapy which has been widely used in Europe, the United States and some countries of South America. However, the use of photodynamic therapy presents some points that need to be clarified: the type of photosynthetic (by way of administration, mode of preparation of therapeutic concentration), the radiation source (type of irradiation parameters: wavelength, energy, exposure time, pulse duration, pulse frequency), methods for determining the biological response, among others. Continuing with our studies, which began in evaluating the distribution of photosensitizes, followed by analysis of the type of cell death and influence of PDT in the process of metastasis, we found the need to understand all the events on a continuum. In this project, aiming to better understand these mechanisms, we propose to evaluate the cellular and molecular events with different photosensitizes, in models in vitro and in vivo. To be used as photosensitizes for PDT have already been approved and new photosensitizes associated with nanotechnology, with the aim of enhancing interaction with the same tumor cells, comparing the signaling pathways, adhesion and cell death activated as well as their effectiveness in eradicating tumor cells. (AU)

Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FONSECA, MARCELO DE OLIVEIRA; DA SILVA, NEWTON SOARES; SOARES, CRISTINA PACHECO. Effect of cortisol on K562 leukemia cells. Revista O Mundo da Saúde, v. 43, n. 4, p. 854-861, OCT-DEC 2019. Web of Science Citations: 0.
DE FARIA SOUZA, ROBERTA KELLY; SILVA CARVALHO, ISABEL CHAVES; DA CUNHA MENEZES COSTA, CAROLINA GENUNCIO; DA SILVA, NEWTON SOARES; PACHECO-SOARES, CRISTINA. Alteration of Surface Glycoproteins After Photodynamic Therapy. Photomedicine and Laser Surgery, v. 36, n. 8, p. 452-456, AUG 2018. Web of Science Citations: 1.
LOPES, K. A. R.; DE CAMPOS VELHO, N. M. R.; PACHECO-SOARES, C. Method of isolation and characterization of Girardia tigrina stem cells. BIOMEDICAL REPORTS, v. 3, n. 2, p. 163-166, MAR 2015. Web of Science Citations: 1.
ALINE LLANOS DE OLIVEIRA; GEISA NOGUEIRA SALLES; JULIANA MACEDO COSTA COUCEIRO; CLAUDIA EBNER; NEWTON SOARES DA SILVA; CRISTINA PACHECO SOARES. Avaliação da atividade mitocondrial no processo de morte celular em células tumorais de mama após tratamento com Ciclosporina A e Photosan3®. Rev. Bras. Eng. Bioméd., v. 29, n. 2, p. 193-198, Jun. 2013.

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