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Evaluation of nano-TiO2 toxic effects in fish

Grant number: 10/06226-2
Support type:Regular Research Grants
Duration: September 01, 2010 - August 31, 2012
Field of knowledge:Biological Sciences - Ecology
Principal Investigator:Vera Lucia Scherholz Salgado de Castro
Grantee:Vera Lucia Scherholz Salgado de Castro
Home Institution: Embrapa Meio-Ambiente. Empresa Brasileira de Pesquisa Agropecuária (EMBRAPA). Ministério da Agricultura, Pecuária e Abastecimento (Brasil). Jaguariúna , SP, Brazil
Assoc. researchers:Claudio Martin Jonsson ; Leonardo Fernandes Fraceto


The production and use of synthetic nanoparticles is rapidly growing. Therefore, the presence of these materials into the environment seems to be inevitable. However, the effects on humans and ecosystems exposed to nanoparticles have not been fully elucidated. Titanium dioxide (TiO2) has several possibilities for industrial use, in cosmetics and even in water treatment. Thus, studies of its toxicity and environmental impact are essential. This project aims to obtain information about the potential ecotoxicological risk of TiO2 nanoparticles (nano-TiO2), establishing an experimental protocol to study its toxicity in a native fish species. The purpose is to evaluate the effects of nano-TiO2 exposure under different illumination conditions, through evaluation of biochemical and genetic biomarkers. The accumulation of such materials in fish tissue will be also determined. It is expected to contribute and participate in the consolidation of nanoecotoxicology in Brazil, supplementing the knowledge about the risks of nanotechnology to the living organisms and ecosystems. (AU)

Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CLEMENTE, Z.; CASTRO, V. L.; FEITOSA, L. O.; LIMA, R.; JONSSON, C. M.; MAIA, A. H. N.; FRACETO, L. F. Biomarker Evaluation in Fish After Prolonged Exposure to Nano-TiO2: Influence of Illumination Conditions and Crystal Phase. Journal of Nanoscience and Nanotechnology, v. 15, n. 7, p. 5424-5433, JUL 2015. Web of Science Citations: 12.
CLEMENTE, Z.; CASTRO, V. L.; JONSSON, C. M.; FRACETO, L. F. Minimal levels of ultraviolet light enhance the toxicity of TiO2 nanoparticles to two representative organisms of aquatic systems. JOURNAL OF NANOPARTICLE RESEARCH, v. 16, n. 8 JUL 25 2014. Web of Science Citations: 18.
CLEMENTE, Z.; CASTRO, V. L. S. S.; MOURA, M. A. M.; JONSSON, C. M.; FRACETO, L. F. Toxicity assessment of TiO2 nanoparticles in zebrafish embryos under different exposure conditions. AQUATIC TOXICOLOGY, v. 147, p. 129-139, FEB 2014. Web of Science Citations: 62.
CLEMENTE, Z.; CASTRO, V. L.; FEITOSA, L. O.; LIMA, R.; JONSSON, C. M.; MAIA, A. H. N.; FRACETO, L. F. Fish exposure to nano-TiO2 under different experimental conditions: Methodological aspects for nanoecotoxicology investigations. Science of The Total Environment, v. 463, p. 647-656, OCT 1 2013. Web of Science Citations: 39.

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