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Short bowel syndrome (SBS): a unique model for evaluating the pro-inflammatory state

Grant number: 10/07643-6
Support Opportunities:Regular Research Grants
Duration: November 01, 2010 - October 31, 2012
Field of knowledge:Health Sciences - Nutrition - Nutritional Analysis of Population
Principal Investigator:Vivian Marques Miguel Suen
Grantee:Vivian Marques Miguel Suen
Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated researchers:Julio Sérgio Marchini ; Letícia Bizari ; Norma Tiraboschi Foss


The Short Bowel Syndrome (SBS) usually presents as characteristics: intense weight loss and poor-absorption of nutrients and fluids, leading to a decrease in intestinal transit time and hence diarrhea. Thus it is necessary monitoring the use of parenteral nutritional support (PNS). Although necessary, this therapy carries some risks to the health of the patient. Since it is known association of long periods of use of the PNS with liver dysfunction or failure, and this coupled with a possible inflammatory status of patients with SBS. Objective: Therefore, the objective of this study is to assess and compare the pro-inflammatory status of two groups with SIC: group that makes use of the PNS (PG) and that group is only ambulatory monitoring (AG), which evolved differently. Methodology: case-control study conducted in HCFMRP / USP with a convenience sample. The intervention will be held in the two groups involved in research and will consist of: food anamnesis (questionnaire Quantitative Food Frequency of consumption), anthropometric measurements (weight, height, BMI, skinfolds, arm circumference) and measures of pro-inflammatory cytokines serum (IL-6; IL-10; TNF-±; TGF-²) and C-reactive protein (CRP). (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BIZARI, LETICIA; DA SILVA SANTOS, ANDRESSA FEIJO; MARCHINI, JULIO SERGIO; MIGUEL SUEN, VIVIAN MARQUES. Anthropometric, food intake differences and aplicability of low-cost instruments for the measurement of body composition in two distinct groups of individuals with short bowel syndrome. NUTRICION HOSPITALARIA, v. 30, n. 1, p. 205-212, . (10/07643-6)
BIZARI, LETICIA; DA SILVA SANTOS, ANDRESSA FEIJO; FOSS, NORMA TIRABOSCHI; MARCHINI, JULIO SERGIO; MIGUEL SUEN, VIVIAN MARQUES. Parenteral nutrition in short bowel syndrome patients, regardless of its duration, increases serum proinflammatory cytokines. Nutrition Research, v. 36, n. 7, p. 751-755, . (10/07643-6)

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