Gene expression in multiple myeloma at diagnosis and after treatment with thalidomide

• Grant number: 01/12901-5
• Support Opportunities: Genome Research Grants
• Start date: May 01, 2002
• End date: December 31, 2004
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Gisele Wally Braga Colleoni
• Grantee: Gisele Wally Braga Colleoni
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil

Abstract

The aims of this study are: 1) to correlate gene expression profiles with clinical staging at diagnosis, cytogenetic abnormalities, cell surface antigens and histology of bone marrow in MM patients; 2) to identify changes in gene expression profiles in MM patients induced by treatment with thalidomide; 3) to correlate eventual heterogeneity of gene expression at diagnosis with therapeutic response, either to standard chemotherapy or to thalidomide; 4) to evaluate the role of SNPs of the coding or promoter regions of selected genes in relation to the susceptibility or the evolution of MM. (AU)