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Follow-up of a cohort of victims of violence derived from an epidemiological study: analysis outcomes, related to brain structures, genetics, and neuropsychological function, and clinical features

Grant number: 10/07432-5
Support Opportunities:Regular Research Grants
Duration: February 01, 2011 - January 31, 2013
Field of knowledge:Health Sciences - Medicine - Psychiatry
Principal Investigator:Marcelo Feijó de Mello
Grantee:Marcelo Feijó de Mello
Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
Associated researchers:Aline Ferri Schoedl ; Jair Borges Barbosa Neto ; Mariana Kneese Flaks ; Nina Leão Marques Valente


We intend to follow-up a cohort of victims of violence, based on an epidemiological study at São Paulo city, that developed (n=43 cases) or not (n= 101 controls) posttraumatic stress disorder (PTSD), and 81 cases with PTSD that looked up for treatment at the outpatient clinic of the program for treatment and study of violence of the Federal university of São Paulo (PROVE)-UNIFESP, and 42 victims of violence, without PTSD. The total sample has 267 subjects, being 124 cases and 143 controls. We will have two subsamples of PTSD patients, from spontaneous and by chance (nested-based case), providing further intra group comparisons. All subjects were administered up to two-years an evaluation battery with socio demographic, clinical, abuse antecedents, subsample performed neuropsychological evaluation, magnetic resonance imaging studies to evaluate volume of specific brain regions, functional brain imaging studies to evaluate dopamine transporter receptor concentration, hypothalamic-pituitary-adrenal axis evaluation using the prednisolone suppression test, candidate genes evaluation (BDNF, glucocorticoid receptors, dopaminergic, serotoninergic systems). All patients with PTSD received treatment based on international guidelines. We intend to evaluate the cohort outcome, after at least two years on the former case-control study, related to their clinical status: remission, relapse, death, non-adherence to treatment and its reasons, and re-evaluate some neuropsychological functions. This cohort evaluation, born from a "nested case control sample" and a spontaneous sample, will produce a original data of great relevance to our reality here in Brazil. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PUPO, MARIANA CADROBBI; SERAFIM, PAULA MARIA; DE MELLO, MARCELO FEIJO. Health-related quality of life in posttraumatic stress disorder: 4 years follow-up study of individuals exposed to urban violence. PSYCHIATRY RESEARCH, v. 228, n. 3, p. 741-745, . (04/15039-0, 10/07432-5)

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