Chitosan films loaded with phytotherapic for wound dressing

• Grant number: 10/17721-4
• Support Opportunities: Regular Research Grants
• Start date: March 01, 2011
• End date: February 28, 2013
• Field of knowledge: Engineering - Biomedical Engineering
• Principal Investigator: Classius Ferreira da Silva
• Grantee: Classius Ferreira da Silva
• Host Institution: Instituto de Ciências Ambientais, Químicas e Farmacêuticas (ICAQF). Universidade Federal de São Paulo (UNIFESP). Campus Diadema. Diadema , SP, Brazil
• Associated researchers: Alfredo Gragnani Filho ; Cristiana Maria Pedroso Yoshida ; Lydia Masako Ferreira

Abstract

Polymeric films are used as wound dressing for burns and wound healing. Healing, anti-inflammatory and antibiotic properties can be induced and/or potentiated with the incorporation of bioactive like phytotherapics. This work will produce chitosan films incorporating aloe vera extract and/or Copaiba oil having the mentioned properties. The films will be prepared by dispersion of the suspension of the bioactive and chitosan on a surface and slow drying. The variables studied in the preparation of the films will be: concentration of chitosan and concentration of bioactive. The films will be evaluated according to the thickness, water permeability, water vapor permeability, microorganism permeability, differential scanning calorimetry, infrared spectroscopy and biological assays (inhibition to bacterial growth, in vitro cytotoxicity and adhesion). The performance of the films containing the phytotherapics will be compared with a commercial dressing (Veloderm) as well as chitosan films containing silver sulfadiazine, an important drug used in burns treatment. The results will serve as a criterion for choosing the films that will be tested in an in vivo study with rats. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BARBOSA, GUSTAVO P.; DEBONE, HENRIQUE S.; SEVERINO, PATRICIA; SOUTO, ELIANA B.; DA SILVA, CLASSIUS F.. Design and characterization of chitosan/zeolite composite films - Effect of zeolite type and zeolite dose on the film properties. Materials Science & Engineering C-Materials for Biological Applications, v. 60, p. 246-254, MAR 1 2016. (10/17721-4)

GENESI, BIANCA P.; DE MELO BARBOSA, RAQUEL; SEVERINO, PATRICIA; RODAS, ANDREA C. D.; YOSHIDA, CRISTIANA M. P.; MATHOR, MONICA B.; LOPES, PATRICIA S.; VISERAS, CESAR; SOUTO, ELIANA B.; DA SILVA, CLASSIUS FERREIRA. Aloe vera and copaiba oleoresin-loaded chitosan films for wound dressings: microbial permeation, cytotoxicity, and in vivo proof of concept. International Journal of Pharmaceutics, v. 634, p. 12-pg., 2023-02-08. (10/17721-4)