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Analysis of the effects of flavonoids in gene expression, methylation and damage to the DNA of canine cells


Cancer is one of the most important causes of mortality for humans and animals. In dogs, it is estimated that 1 in every 3-4 animals will develop some type of cancer, two times more than humans. Flavonoids, substances present in several plant species, are considered promising substances for development of drugs to be used in prevention and combat of the disease. However, studies on their mechanisms of action and the relevance of the different effects on the cellular genetic material are still required. Therefore, the overall objective of this project is to analyze the effects of flavonoids in the canine macrophage cell line DH82, originated from a histiocytoma, with special focus on global DNA methylation, induction of lesions in the DNA, expression of genes related to DNA repair, tumor suppressors and genes coding DNA metiltransferases and topoisomerases. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SILVA, GABRIEL; FACHIN, ANA LUCIA; BELEBONI, RENE O.; FRANCA, SUZELEI C.; MARINS, MOZART. In Vitro Action of Flavonoids in the Canine Malignant Histiocytic Cell Line DH82. Molecules, v. 18, n. 12, p. 15448-15463, DEC 2013. Web of Science Citations: 8.

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