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Evaluating remineralizers and desensitizers agents in dental bleaching treatment: in vitro and in vivo study

Grant number: 10/12032-6
Support type:Regular Research Grants
Duration: March 01, 2011 - August 31, 2013
Field of knowledge:Interdisciplinary Subjects
Principal researcher:Camila Tirapelli
Grantee:Camila Tirapelli
Home Institution: Faculdade de Odontologia de Ribeirão Preto (FORP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Assoc. researchers:Edgar Dutra Zanotto ; Heitor Panzeri ; Oscar Peitl Filho


The aim of this project is to evaluate in vitro and in vivo the effect of dental bleaching agents, carbamide peroxide 16% (T1) and hydrogen peroxide 35% (T2) together with desensitizers/remineralizer agents, Sensodyne® dentifrice (D1); experimental dentifrice with 7,5% of Biosilicate micro-particles (D2); Odontis RX® dentifrice (D3); Sorriso® dentifrice (D4); Biosilicate micro-particles paste, 1:1 (D5), Desensebilize Nano P (D6), bioglass type 45S5 paste, 1:1 (D7); GC= distilled water, in the experimental groups: T1/D1; T1/D2; T1/D3; T1/D4; T1/D5; T1/D6; T1/D7; T1/GC e T2/D1; T2/D2; T2/D3; T2/D4; T2/D5; T2/D6; T2/D7; T2/GC. In the in vitro study, microhardness and roughness measurements, and images using scanning electron microscopy (SEM) will be made on samples of bovine dental enamel and dentin (4x4x3mm; n=10 por grupo) before and after the treatement with the bleaching gels (T1= 14 days/ 04 hours/day; T2=single session) and the desensitizers/remineralizer agents. In the clinical study, the volunteers (n=10 per group) will be evaluated regarding dentin hypersensitivity (DH), using visual analogue scale, before the beginning of the treatments (T1 and T2) and during the next 14 days (1º, 3º, 7º, 10º and 14º days) in which the desensitizers/remineralizer agents (there´s no control group in the clinical experiments) will be aplying. Data will be analysed intra and inter-group, statisticaly. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PINTADO-PALOMINO, KAREN; VASCONCELOS BARROS DE ALMEIDA, CECILIA VILELA; GONCALVES DA MOTTA, RAPHAEL JURCA; PARISE FORTES, JOAO HENRIQUE; TIRAPELLI, CAMILA. Clinical, double blind, randomized controlled trial of experimental adhesive protocols in caries-affected dentin. CLINICAL ORAL INVESTIGATIONS, v. 23, n. 4, p. 1855-1864, . (13/07793-6, 10/12032-6)

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