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Expression of markers related to cell differentiation potential in human fetus dental germ

Grant number: 10/08085-7
Support Opportunities:Regular Research Grants
Duration: May 01, 2011 - April 30, 2013
Field of knowledge:Biological Sciences - Morphology - Anatomy
Principal Investigator:Marcelo Cavenaghi Pereira da Silva
Grantee:Marcelo Cavenaghi Pereira da Silva
Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
Associated researchers:Adriana da Costa Neves ; Irina Kerkis ; Juliana Malta da Cunha


Technological and scientific advancement has provided considerable benefits for humanity through the introduction of new therapies and, in this sense, many surveys have been conducted with the use of stem cells and encouraging results with regard to the benefits of treatment and in some cases even cure. Stem cells are cells that can generate different cell lines and can be collected from different adult tissues or embryonic tissues. Among the adult tissues that have a large number of stem cells viable, ease of obtention in a little intrusive method considered are stem cells obtained from deciduous teeth pulp.Stem cells derived from the pulp deciduous teeth has been widely studied because of their ability to differentiate into a variety of cell lines in the presence of various chemical mediators. The formation of teeth in humans begins around the third month of intrauterine development and the present study is to analyze the expression of several proteins related to cell differentiation potential of cell populations that make up the mandible tooth germ of human fetuses.Mandible of 20 human fetuses of both genders and of different gestational periods will be used and after routine paraffin inclusion, they will be subjected to immunohistochemistry for the following stem cell markers: NANOG, STAT-3, OCT 4, SOX-2 and PDGF. Immunostaining of these proteins in different cell populations will be analyzed by morphometry. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DA CUNHA, JULIANA MALTA; DA COSTA-NEVES, ADRIANA; KERKIS, IRINA; PEREIRA DA SILVA, MARCELO CAVENAGHI. Pluripotent stem cell transcription factors during human odontogenesis. Cell and Tissue Research, v. 353, n. 3, p. 435-441, . (10/08085-7)

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