Vitamin D deficiency in oncological critically ill patients

• Grant number: 10/08529-2
• Support Opportunities: Regular Research Grants
• Start date: May 01, 2011
• End date: April 30, 2013
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Lucia da Conceição Andrade
• Grantee: Lucia da Conceição Andrade
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated researchers: Antonio Carlos Seguro ; Filomena Regina Barbosa Gomes Galas ; Maria Heloisa Massola Shimizu ; Rildo Aparecido Volpini ; Rosa Maria Affonso Moysés

Abstract

The association between vitamin D deficiency and chronic illness is well-known. Vitamin D deficiency has been associated with increased mortality in the general population. Despite this knowledge, vitamin D insufficiency is seldom considered and rarely replaced adequately, if at all, in critically ill patients in intensive care. Vitamin D deficiency is rarely considered or treated in critically ill patients. However, it has been reported cases of life-threatening hypocalcemia secondary to vitamin D deficiency, highlighting potential acute complications. The prevalence of vitamin D deficiency and its significance in the intensive care unit are unknown. We propose a prospective study of the vitamin D status in oncological ICU patients referred to Instituto do Câncer do Estado de São Paulo. Demographic, physiological, and biochemical variables will be recorded, including the Simplified Acute Physiology Score II (SAPS II). 25-vitamin; 1,25 vitamin; PTH; FGF 23; C cystatin will be measured. Urinary biochemical parameters will be collected from all patients at the admission (FENa, FEK, FEMg, FECa, FEP). We will analyze the urinary biomarkers (NGAL and Klotho). The prevalence of hypovitaminosis D in the current study will be associated with adverse outcomes, mortality at day 28 and 90, and quality of live. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

COELHO, FERNANDA OLIVEIRA; JORGE, LECTICIA BARBOSA; DE BRAGANCA VICIANA, ANA CAROLINA; SANCHES, TALITA R.; DOS SANTOS, FERNANDO; HELOU, CLAUDIA M. B.; IRIGOYEN, MARIA CLAUDIA; KURO-O, MAKOTO; ANDRADE, LUCIA. Chronic nicotine exposure reduces klotho expression and triggers different renal and hemodynamic responses in klotho-haploinsufficient mice. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, v. 314, n. 5, p. F992-F998, MAY 2018. (10/19012-0, 10/08529-2, 12/03025-1)

JORGE, LECTICIA B.; COELHO, FERNANDA O.; SANCHES, TALITA R.; MALHEIROS, DENISE M. A. C.; DE SOUZA, LEANDRO EZAQUIEL; DOS SANTOS, FERNANDO; LIMA, LARISSA DE SA; SCAVONE, CRISTOFORO; IRIGOYEN, MARIA; KURO-O, MAKOTO; et al. Klotho deficiency aggravates sepsis-related multiple organ dysfunction. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, v. 316, n. 3, p. F438-F448, MAR 2019. (10/19012-0, 12/03025-1, 10/08529-2)