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Acquisition of a multi-stage mass spectrometer for a Laboratory / Facility in the Chemistry Department of the University of São Paulo Ribeirão Preto School of Philosophy, Science and Literature

Grant number: 09/54094-0
Support Opportunities:Multi-user Equipment Program
Duration: August 01, 2010 - July 31, 2012
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal Investigator:Luiz Alberto Beraldo de Moraes
Grantee:Luiz Alberto Beraldo de Moraes
Host Institution: Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (FFCLRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
As informações de acesso ao Equipamento Multiusuário são de responsabilidade do Pesquisador responsável
EMU web page: Página do Equipamento Multiusuário não informada
Type of equipment: Tipo de Equipamento Multiusuário não informado
Manufacturer: Fabricante não informado
Model: Modelo não informado


Recent advances in instrumentation, principally in the modalities of ionization and mass analysis, have made the mass spectrometer one of the most versatile devices for use in the analytical sciences. The discovery and development of electrospray ionization (ESI) revolutionized mass spectrometry, allowing the ionization of thermally unstable molecules, such as proteins, carbohydrates, inorganic complexes, and glycosylated compounds, which are impossible to analyze by electron ionization. The principal objective of this proposal is the acquisition of a mass spectrometer with ESI to be employed in the analytical science center of the Chemistry Department of the USP Ribeirão Preto School of Philosophy, Science, and Literature, which currently has no equipment of this type. The proposal involves 29 researchers and more than 90 graduate students, at various institutions, working in diverse areas of knowledge, such as organic and inorganic synthesis, chemistry of natural products, materials science, characterization of bioactive secondary metabolites, degradation of drugs and pesticides, and the biotransformation of drugs, as well as affinity and multidimensional chromatography. Because of its analytical versatility, the mass spectrometer requested should meet the basic needs of the various research groups, as well as furthering the understanding of the processes involved, thereby accelerating the research of the groups involved in the proposal and of other groups that might avail themselves of the Analytical Science Center facilities. It should be noted that the Center has the necessary infrastructure for the installation and immediate activation of the equipment requested: 35 m2 of available floor space; a liquid nitrogen station; a high level of technical expertise; and, principally, a professor specializing in analytical methods that require mass spectrometry. These factors ensure that the spectrometer will be maintained in good working order and that the full analytical potential of the equipment will be achieved. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
LIMA, ANDREISA FABRI; RIBEIRO, LEANDRO DO PRADO; PADOAN GONCALVES, GABRIEL LUIZ; MAIMONE, NAYDJA MORALLES; GISSI, DANILO SOARES; DE LIRA, SIMONE POSSEDENTE; VENDRAMIM, JOSE DJAIR. Searching for bioactive compounds from Solanaceae: lethal and sublethal toxicity to Spodoptera frugiperda and untargeted metabolomics approaches. JOURNAL OF PEST SCIENCE, . (13/50228-8, 09/54094-0)
CANOVAS MARTINEZ, ANA FLAVIA; BERALDO MORAES, LUIZ ALBERTO. Liquid chromatography- tandem mass spectrometry characterization of five new leucinostatins produced by Paecilomyces lilacinus CG-189. JOURNAL OF ANTIBIOTICS, v. 68, n. 3, p. 178-184, . (09/54094-0)

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