Gastroprotective activity of menthol and epicatechin: studying its activity by morphological, physiological and pharmacological view

• Grant number: 10/08536-9
• Support Opportunities: Regular Research Grants
• Duration: May 01, 2011 - April 30, 2013
• Field of knowledge: Biological Sciences - Morphology - Histology
• Principal Investigator: Claudia Helena Pellizzon
• Grantee: Claudia Helena Pellizzon
• Host Institution: Instituto de Biociências (IBB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
• Associated researchers: Clélia Akiko Hiruma Lima

Abstract

Gastric ulcer is the most common gastrointestinal disease in clinical, characterized by lesions in the gastric mucosa caused by an unbalance between protective factors, such as mucus, bicarbonate, nitric oxide, prostaglandins, glutationa; and aggressive factor, such as hydrochloric acid, inadequate blood flow, alcohol ingestion, smoking, non steroidal anti-inflammatory drugs, stress and the bacterium Helicobacter pylori. Gastric ulcer is considered the new century epidemic disease, over 4 million people present it and, every year 350 thousands new cases are diagnosed and it's estimated about 3 thousands obits only in USA. The current available treatments are very efficient, although the drugs show a series of collateral effects, as hipergastrenemia which may cause gastric cancer. Due to these reasons, the study of new drugs capable of protecting the gastric mucosa is important. Menthol is a cyclic terpene found in plants of gender Mentha, economically important, moving over 300 million dollars per year and presents versatile medical use as drug, cosmetic and flavoring. In folk medicine, its largely used for gastrointestinal diseases, dyspepsia and headache. Epicatechin is a polophenol with antioxidant proprieties present in many plants with medical uses, which are widely used in gastrointestinal diseases. Epicatechin is a poliphenol with antioxidant proprieties, which is present in many medical plants that are widely used against gastronintestinal diseases. (AU)

Scientific publications

(6)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ROZZA, A. L.; HIRUMA-LIMA, C. A.; TAKAHIRA, R. K.; PADOVANI, C. R.; PELLIZZON, C. H.. Effect of menthol in experimentally induced ulcers: Pathways of gastroprotection. Chemico-Biological Interactions, v. 206, n. 2, p. 272-278, NOV 25 2013. (10/08536-9)

ROZZA, ARIANE LEITE; DE FARIA, FELIPE MEIRA; SOUZA BRITO, ALBA REGINA; PELLIZZON, CLAUDIA HELENA. The Gastroprotective Effect of Menthol: Involvement of Anti-Apoptotic, Antioxidant and Anti-Inflammatory Activities. PLoS One, v. 9, n. 1, JAN 21 2014. (10/08536-9)

ROZZA, A. L.; HIRUMA-LIMA, C. A.; TANIMOTO, A.; PELLIZZON, C. H.. Morphologic and Pharmacological Investigations in the Epicatechin Gastroprotective Effect. Evidence-based Complementary and Alternative Medicine, v. 2012, p. 8-pg., 2012-01-01. (10/08536-9)

DE PAULA VASCONCELOS, PAULO CESAR; SEITO, LEONARDO NOBORU; DI STASI, LUIZ CLAUDIO; HIRUMA-LIMA, CLELIA AKIKO; PELLIZZON, CLAUDIA HELENA. Epicatechin Used in the Treatment of Intestinal Inflammatory Disease: An Analysis by Experimental Models. Evidence-based Complementary and Alternative Medicine, 2012. (10/08536-9, 02/05503-6)

ROZZA, A. L.; HIRUMA-LIMA, C. A.; TANIMOTO, A.; PELLIZZON, C. H.. Morphologic and Pharmacological Investigations in the Epicatechin Gastroprotective Effect. Evidence-based Complementary and Alternative Medicine, 2012. (10/08536-9)

DE PAULA VASCONCELOS, PAULO CESAR; SEITO, LEONARDO NOBORU; DI STASI, LUIZ CLAUDIO; HIRUMA-LIMA, CLELIA AKIKO; PELLIZZON, CLAUDIA HELENA. Epicatechin Used in the Treatment of Intestinal Inflammatory Disease: An Analysis by Experimental Models. Evidence-based Complementary and Alternative Medicine, v. 2012, p. 12-pg., 2012-01-01. (02/05503-6, 10/08536-9)