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Evaluation of the effect of 15d-PGJ2-loaded on polymeric biodegradable nanoparticles to control the evolution of the experimental periodontal disease


Recently, the peroxisome proliferator-activated gama and its natural agonist (15d-PGJ2) has been demonstrated excellent anti-inflammatory results in experimental models such as pancreatitis, sepsis and rheumatoid arthritis and also possess a potent analgesic action. Nowadays, it has been employed the polymeric nanostructures system to release drugs. This system has the ability to change the therapeutic properties of the drug leading to several advantages such as increase in stability, slow and prolonged release, decreased toxicity, tissue-specific target, among others. Thus, the present study has the objective to develop a nanotechonologic formulation as a drug carrier for 15d-PGJ2 as well as to investigate the immunomodulatory effects of this formulation, looking for a new system for future use on the treatment of periodontal disease. (AU)

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Scientific publications (6)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CLEMENTE-NAPIMOGA, JULIANA T.; MOREIRA, JUSCELAINE A.; GRILLO, RENATO; DE MELO, NATHALIE F. S.; FRACETO, LEONARDO F.; NAPIMOGA, MARCELO H.. 15d-PGJ2-loaded in nanocapsules enhance the antinociceptive properties into rat temporomandibular hypernociception. Life Sciences, v. 90, n. 23-24, p. 944-949, . (10/15014-9)
NAPIMOGA, MARCELO HENRIQUE; DIAS DEMASI, ANA PAULA; BOSSONARO, JERUZA P.; DE ARAUJO, VERA CAVALCANTI; CLEMENTE-NAPIMOGA, JULIANA TRINDADE; MARTINEZ, ELIZABETH FERREIRA. Low doses of 15d-PGJ2 induce osteoblast activity in a PPAR-gamma independent manner. International Immunopharmacology, v. 16, n. 2, p. 131-138, . (10/15014-9)
BORGHI, SERGIO M.; MIZOKAMI, SANDRA S.; PINHO-RIBEIRO, FELIPE A.; FATTORI, VICTOR; CRESPIGIO, JEFFERSON; CLEMENTE-NAPIMOGA, JULIANA T.; NAPIMOGA, MARCELO H.; PITOL, DIMITRIUS L.; ISSA, JOAO P. M.; FUKADA, SANDRA Y.; et al. The flavonoid quercetin inhibits titanium dioxide (TiO2)-induced chronic arthritis in mice. JOURNAL OF NUTRITIONAL BIOCHEMISTRY, v. 53, p. 81-95, . (15/09034-0, 10/15014-9)
RUIZ-MIYAZAWA, KENJI W.; STAURENGO-FERRARI, LARISSA; PINHO-RIBEIRO, FELIPE A.; FATTORI, VICTOR; ZANINELLI, TIAGO H.; BADARO-GARCIA, STEPHANIE; BORGHI, SERGIO M.; ANDRADE, KETLEM C.; CLEMENTE-NAPIMOGA, JULIANA T.; ALVES-FILHO, JOSE C.; et al. 15d-PGJ(2)-loaded nanocapsules ameliorate experimental gout arthritis by reducing pain and inflammation in a PPAR-gamma-sensitive manner in mice. SCIENTIFIC REPORTS, v. 8, . (13/08216-2, 10/15014-9, 11/19670-0)
NAPIMOGA, MARCELO H.; DA SILVA, CARLOS A. T.; CARREGARO, VANESSA; FARNESI-DE-ASSUNCAO, THAIS S.; DUARTE, POLIANA M.; DE MELO, NATHALIE F. S.; FRACETO, LEONARDO F.. Exogenous Administration of 15d-PGJ(2)-Loaded Nanocapsules Inhibits Bone Resorption in a Mouse Periodontitis Model. JOURNAL OF IMMUNOLOGY, v. 189, n. 2, p. 1043-1052, . (10/15014-9)
RUIZ-MIYAZAWA, KENJI W.; BORGHI, SERGIO M.; PINHO-RIBEIRO, FELIPE A.; STAURENGO-FERRARI, LARISSA; FATTORI, VICTOR; FERNANDES, GLAURA S. A.; CASELLA, ANTONIO M.; ALVES-FILHO, JOSE C.; CUNHA, THIAGO M.; CUNHA, FERNANDO Q.; et al. The citrus flavanone naringenin reduces gout-induced joint pain and inflammation in mice by inhibiting the activation of NF kappa B and macrophage release of IL-1 beta. Journal of Functional Foods, v. 48, p. 106-116, . (13/08216-2, 11/19670-0, 10/15014-9)

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