In vivo evaluation of potential endocrine disruption by environmental contaminants

• Grant number: 11/09870-2
• Support Opportunities: Regular Research Grants
• Start date: August 01, 2011
• End date: January 31, 2014
• Field of knowledge: Health Sciences - Medicine - Pathological Anatomy and Clinical Pathology
• Principal Investigator: João Lauro Viana de Camargo
• Grantee: João Lauro Viana de Camargo
• Host Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
• Associated researchers: Carla Adriene da Silva Franchi ; Gisela de Aragão Umbuzeiro ; Wilma de Grava Kempinas

Abstract

Endocrine disrupting chemicals are substances able to interfere on the hormonal homeostasis in humans and other animals. Usually they have estrogenic or antiandrogenic activities. This proposal comprises projects that will evaluate in rats the potential of three enviromental agents jto exert endocrine disruption: 1) drinking water, 2) sewage sludge and 3) three agricultural fungicides prochloraz, propiconazole e miclobutanil, widely used in this coiuntry. This project has the collaboration of the aboratório de Química Ambiental - Instituto de Química da UNICAMP e da Companhia de Tecnologia e Saneamento Ambiental do Estado de São Paulo (CETESB)that will provide respectively samples of drinking water and of sewage sludge from especific treatment plants. The endocrine disruption effects will be evaluated by harmonized and validated assays. (AU)