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In vivo evaluation of potential endocrine disruption by environmental contaminants


Endocrine disrupting chemicals are substances able to interfere on the hormonal homeostasis in humans and other animals. Usually they have estrogenic or antiandrogenic activities. This proposal comprises projects that will evaluate in rats the potential of three enviromental agents jto exert endocrine disruption: 1) drinking water, 2) sewage sludge and 3) three agricultural fungicides prochloraz, propiconazole e miclobutanil, widely used in this coiuntry. This project has the collaboration of the aboratório de Química Ambiental - Instituto de Química da UNICAMP e da Companhia de Tecnologia e Saneamento Ambiental do Estado de São Paulo (CETESB)that will provide respectively samples of drinking water and of sewage sludge from especific treatment plants. The endocrine disruption effects will be evaluated by harmonized and validated assays. (AU)

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