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Evaluation of the humidification and warming of inspired gases in pediatric patients under general anesthesia with different fresh gas flows and use of heat and moisture exchanger

Grant number: 11/13545-0
Support type:Regular Research Grants
Duration: October 01, 2011 - September 30, 2013
Field of knowledge:Health Sciences - Medicine - Surgery
Principal researcher:Jose Reinaldo Cerqueira Braz
Grantee:Jose Reinaldo Cerqueira Braz
Home Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
Assoc. researchers:Leandro Gobbo Braz ; Norma Sueli Pinheiro Módolo


SummaryDuring anesthesia, tracheal intubation prevents contact of the gaseous mixture with the mucosa of the upper respiratory tract. Thus, it can lead to important changes in the physiological mechanism of heating and humidification of inspired gases. The use of inspiratory mixture without adequate heating and humidification can result in important changes in morphological and functional properties of the airways and lung function. Thus, the humidification and warming of inspired gases are important in patients undergoing tracheal intubation and mechanical ventilation. On mechanical ventilation devices are used for heating and humidifying inspired gases, such as heat and moisture exchanger (PCU). In anaesthesiology, it is considered that the circular ventilation systems with CO2 absorber, when associated with low fresh gas flow (FGF) <1 L / min, have properties of humidification and warming of inspired gases. With the use of FGF higher (> 1 L / min) these properties are attenuated. The study to compare the values of humidity and temperature of the gas mixture inhaled in pediatric patients undergoing general anesthesia with or without PCU under low and high flow FGF. After approval by the Research Ethics Committee and obtaining informed consent, we analyzed 40 pediatric patients 10 to 30 kg, ASA physical status I or II who will undergo surgical procedures under general anesthesia. Will be randomly assigned to four groups:PCU1L (n = 10): FGF = 1l/min and use of PCU in the breathing circuit.PCU3L (n = 10): FGF = 3L/min and use of PCU in the breathing circuit.1L (n = 10): FGF = 1l/min without the use of PCU in the breathing circuit.3L (n = 10): FGF = 3L/min without the use of PCU in the breathing circuit.Will measure temperature and relative and absolute humidity of inspired gases and core temperature of patients during anesthesia. The measures will be at 5, 20, 40, 60 and 80 minutes after the breathing circuit. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BICALHO, GUSTAVO P.; BRAZ, LEANDRO G.; DE JESUS, LARISSA S. B.; PEDIGONE, CESAR M. C.; DE CARVALHO, LIDIA R.; MODOLO, NORMA S. P.; BRAZ, JOSE R. C. The Humidity in a Drager Primus Anesthesia Workstation Using Low or High Fresh Gas Flow and With or Without a Heat and Moisture Exchanger in Pediatric Patients. ANESTHESIA AND ANALGESIA, v. 119, n. 4, p. 926-931, OCT 2014. Web of Science Citations: 1.

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