Caloric restriction in obese patients with mild cognitive impairment: effects on adiposity, comorbidity and cognition

• Grant number: 11/06194-6
• Support Opportunities: Regular Research Grants
• Start date: November 01, 2011
• End date: October 31, 2013
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Cintia Cercato
• Grantee: Cintia Cercato
• Host Institution: Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
• Associated researchers: ALFREDO HALPERN ; Nídia Celeste Horie

Abstract

With the aging population and increasing prevalence of obesity, it is important to identify strategies that minimize their impact on health. Obesity has been associated with cognitive impairments, lower blood flow, metabolic activity and brain volume. Longitudinal studies show obesity in adulthood as a risk factor for Alzheimer's disease in the elderly. The mild cognitive impairment (MCI) is a condition that may precede dementia. Objectives: To evaluate the cognitive performance of obese patients with MCI and the effect of weight loss induced by caloric restriction on cognition, conversion to dementia, to assess weight loss, changes in inflammatory and metabolic parameters, change in physical capacity, performance in neuropsychological tests and correlate with effects of the intervention. Methods: A sample of 80 patients aged e 60 years, obese, independent for most of the instrumental activities of daily living, literate, able to walk, with CCL. They will be randomized to two groups that will be followed for 12 months. The control group will receive conventional medical care. The intervention group will receive nutritional counseling individually and in groups, aiming to promote weight loss through caloric restriction, and medical monitoring. Everyone will be advised to physical activity. Before and after 12 months patients will be evaluated for anthropometry, body composition, physical performance, control of comorbidities, laboratory tests (glucose, insulin, lipid profile, leptin, adiponectin, interleukin 6, tumor necrosis factor alpha, CRP), Genotyping apolipoprotein E, neuropsychological battery, questionnaires about activities of daily living, physical activity and diet. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

HORIE, NIDIA CELESTE; SERRAO, VALERIA T.; SIMON, SHARON SANZ; POLO GASCON, MARIA RITA; DOS SANTOS, ALESSANDRA XAVIER; ZAMBONE, MARIA AQUIMARA; DEL BIGIO DE FREITAS, MARTA MERENCIANA; CUNHA-NETO, EDECIO; MARQUES, EMERSON LEONILDO; HALPERN, ALFREDO; et al. Cognitive Effects of Intentional Weight Loss in Elderly Obese Individuals With Mild Cognitive Impairment. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, v. 101, n. 3, p. 1104-1112, MAR 2016. (11/06194-6)