Clinical effects, hemodynamic and blood gas continuous infusion of propofol with or without tramadol in sheep underwent laparoscopic surgery

• Grant number: 11/19332-8
• Support Opportunities: Regular Research Grants
• Start date: January 01, 2012
• End date: March 31, 2014
• Field of knowledge: Agronomical Sciences - Veterinary Medicine - Animal Clinics and Surgery
• Principal Investigator: Carlos Augusto Araújo Valadão
• Grantee: Carlos Augusto Araújo Valadão
• Host Institution: Faculdade de Ciências Agrárias e Veterinárias (FCAV). Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Jaboticabal , SP, Brazil

Abstract

The surgical techniques used in invasive gastroenterology require instrumentation that is time-consuming obstacle to the maintenance of stable conditions of anesthesia and especially analgesia. In general, the Videolaparoscopy due to abdominal distension, often compromise the cardiorespiratory function and brings inconvenience to the anesthesia. As a result, the techniques and anesthetics used should interfere minimally in physiological variables. Tramadol, a potent analgesic, has been used in domestic species, including epidural. However, the efficacy of tramadol has not been tested by continuous infusion during surgery, in Videolaparoscopy. Considering this argument, 24 sheep will be induced to anesthesia with propofol ( 6.0 mg / kg / IV). Immediately thereafter, the animals receive continuous infusion of propofol (0.5 mg / kg / min.) (GP, n = 6), infusion of propofol (0.5 mg / kg / min) associated with the bolus of 1.5 mg / kg followed by infusion of tramadol 1.3 mg / kg / h (GT1, 3, n = 6), infusion of propofol (0.5 mg / kg / min.) associated with the bolus of 3.0 mg / kg followed tramadol infusion of 2.6 mg / kg / h (GT2, 6, n = 6) or infusion of propofol (0.5 mg / kg / min.) associated with the 2.0 mg / kg tramadol epidural(GT2b, n = 6 ). Will be assessed hemodynamic, respiratory and metabolic disorders during the pre, intra and post-operatively. Concurrently, an assessment will be the degree and duration of analgesia by means of scores, including the process of trial required by the application of analgesics as rescue medication postoperatively (AU)