Metabolic control of insulin secretion in islets of Langerhans from mice submitted to experimental protein malnourishment and obesity

• Grant number: 11/19536-2
• Support Opportunities: Regular Research Grants
• Start date: February 01, 2012
• End date: January 31, 2014
• Field of knowledge: Biological Sciences - Physiology - Physiology of Organs and Systems
• Principal Investigator: Everardo Magalhães Carneiro
• Grantee: Everardo Magalhães Carneiro
• Host Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated researchers: Claudio Cesar Zoppi

Abstract

Epidemiological data shows obesity and type 2 diabetes burst in developing countries and its relationship with imbalanced diet consumption throughout life span. Insulin secretion impairment is pointed as one of the main alterations related with the incidence of these diseases. Our group has shown several diet-induced molecular and functional effects upon insulin secretion mechanism in protein malnutrition and obesity models. Our hypothesis is that changes in Metabolic Coupling Factors production such as; NADPH, malonyl-CoA, glutamate, etc., could be an additional mechanism to explain impaired insulin secretion in these models. Therefore, our objective is to investigate molecular and functional mechanisms involved with the metabolic control of stimulus/secretion coupling in islets from protein malnourished mice followed by a high fat diet-induced obesity. In addition, this project would also allow the establishment of new methodologies still not employed in the routine of our laboratory. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

LEITE, NAYARA CARVALHO; DE PAULA, FLAVIA; BORCK, PATRICIA CRISTINE; VETTORAZZI, JEAN FRANCIESCO; SOUTO BRANCO, RENATO CHAVES; LUBACZEUSKI, CAMILA; BOSCHERO, ANTONIO CARLOS; ZOPPI, CLAUDIO CESAR; CARNEIRO, EVERARDO MAGALHAES. Protein malnutrition potentiates the amplifying pathway of insulin secretion in adult obese mice. SCIENTIFIC REPORTS, v. 6, SEP 16 2016. (11/19536-2, 13/07607-8, 11/09012-6)