Systemic markers of inflammation in chronic periodontal disease in dogs

• Grant number: 11/21340-9
• Support Opportunities: Regular Research Grants
• Start date: February 01, 2012
• End date: January 31, 2014
• Field of knowledge: Agronomical Sciences - Veterinary Medicine - Animal Clinics and Surgery
• Principal Investigator: Marco Antonio Gioso
• Grantee: Marco Antonio Gioso
• Host Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Periodontitis is an infectious chronic inflammatory disease that affects the supporting tissues (gums) and support (cementum, periodontal ligament and alveolar bone) of the teeth, in other words, the periodontium. Like other infections, periodontal pathogens have been considered candidates for triggering the inflammatory response in atherosclerosis. Moreover, it has been proposed that periodontitis patients have high circulating levels of some systemic markers of inflammation, such as interleukins 1, 6 and 10 (IL-1, IL-6 and IL-10) and tumor necrosis factor- ± (TNF-±). In humans, several recent studies conclude that periodontitis itself increases the serum levels of these inflammatory cytokines. However, in dogs has not found work by measuring the levels of these cytokines in patients with periodontitis or gingivitis. This study aims to evaluate the influence of periodontitis in dogs in the emergence or worsening of systemic diseases such as cardiovascular disease, by measuring the aforementioned inflammatory cytokines, known to act as systemic inflammatory markers. (AU)