Laser application in pain control and tissue stimulation: from basic research to clinical application

• Grant number: 11/22268-0
• Support Opportunities: Regular Research Grants
• Start date: May 01, 2012
• End date: April 30, 2014
• Field of knowledge: Biological Sciences - Morphology - Anatomy
• Principal Investigator: Marucia Chacur
• Grantee: Marucia Chacur
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

The peripheral nerve injury in humans often results in persistent or chronic neuropathic pain characterized by spontaneous burning pain accompanied by allodynia and hyperalgesia. The inferior alveolar nerve injury used in this project is related to routine dental practice for being a constant target of anesthetics used in treatment of lower teeth, and the proximity of their way to the region of surgical extraction of third molar teeth. This is of great relevance to the dentist because it causes physiological and psychological disorders, in addition to frequent loss of sensation and pain. Experimental studies have been developed to better understand the pathophysiological mechanisms of nerve regeneration and its complications. In this project we will associate basic research to clinical application. We use the model of peripheral nerve injury to the face which associates with laser therapy to stimulate nerve repair in experimental animals and patients undergoing dental procedures and for some reason had injuries of the inferior alveolar nerve and temporomandibular joint dysfunction. Still, we evaluate the pain sensitivity before induction of injury, and after treatment with laser therapy.So we hope to increase the knowledge of the mechanisms of nerve repair during treatment with laser therapy, this may contribute to the development of a more efficient treatment protocol in patients with neuropathic pain. (AU)

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MARTINS, DANIEL DE OLIVEIRA; DOS SANTOS, FABIO MARTINEZ; DE OLIVEIRA, MARA EVANY; DE BRITTO, LUIZ R. G.; DIAS LEMOS, JOSE BENEDITO; CHACUR, MARUCIA. Laser Therapy and Pain-Related Behavior after Injury of the Inferior Alveolar Nerve: Possible Involvement of Neurotrophins. JOURNAL OF NEUROTRAUMA, v. 30, n. 6, p. 480-486, MAR 2013. (11/22268-0, 10/20026-6)

GIARDINI, ALINE CAROLINA; DOS SANTOS, FABIO MARTINEZ; DA SILVA, JOYCE TEIXEIRA; DE OLIVEIRA, MARA EVANY; MARTINS, DANIEL OLIVEIRA; CHACUR, MARUCIA. Neural Mobilization Treatment Decreases Glial Cells and Brain-Derived Neurotrophic Factor Expression in the Central Nervous System in Rats with Neuropathic Pain Induced by CCI in Rats. PAIN RESEARCH & MANAGEMENT, v. 2017, p. 9-pg., 2017-01-01. (10/20026-6, 14/24533-0, 11/22268-0, 12/05840-4, 12/24408-6)

GIARDINI, ALINE CAROLINA; DOS SANTOS, FABIO MARTINEZ; DA SILVA, JOYCE TEIXEIRA; DE OLIVEIRA, MARA EVANY; MARTINS, DANIEL OLIVEIRA; CHACUR, MARUCIA. Neural Mobilization Treatment Decreases Glial Cells and Brain-Derived Neurotrophic Factor Expression in the Central Nervous System in Rats with Neuropathic Pain Induced by CCI in Rats. PAIN RESEARCH & MANAGEMENT, 2017. (14/24533-0, 12/24408-6, 10/20026-6, 12/05840-4, 11/22268-0)

DA SILVA, JOYCE TEIXEIRA; DOS SANTOS, FABIO MARTINEZ; GIARDINI, ALINE CAROLINE; MARTINS, DANIEL DE OLIVEIRA; DE OLIVEIRA, MARA EVANY; CIENA, ADRIANO POLICAN; GUTIERREZ, VANESSA PACCIARI; WATANABE, II-SEI; DE BRITTO, LUIZ ROBERTO G.; CHACUR, MARUCIA. Neural mobilization promotes nerve regeneration by nerve growth factor and myelin protein zero increased after sciatic nerve injury. GROWTH FACTORS, v. 33, n. 1, p. 8-13, FEB 2015. (11/22268-0)

ROCHA, P. A.; FERREIRA, A. F. B.; DA SILVA, J. T.; ALVES, A. S.; MARTINS, D. O.; BRITTO, L. R. G.; CHACUR, M.. Effects of selective inhibition of nNOS and iNOS on neuropathic pain in rats. Molecular and Cellular Neuroscience, v. 105, JUN 2020. (11/22268-0, 17/05218-5)