| Grant number: | 11/14520-0 |
| Support Opportunities: | Regular Research Grants |
| Start date: | April 01, 2012 |
| End date: | March 31, 2014 |
| Field of knowledge: | Health Sciences - Medicine |
| Principal Investigator: | Fernando Guimarães |
| Grantee: | Fernando Guimarães |
| Host Institution: | Centro de Atenção Integral à Saúde da Mulher (CAISM). Hospital da Mulher Professor Doutor José Aristodemo Pinotti. Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil |
| Associated researchers: | Carlos Alberto Petta ; Sophie Françoise Mauricette Derchain |
Abstract
We have shown recently the possibility of generating effector cell preparations enriched with CD56+ lymphocytes, NK and NKT-like, by ex vivo expansion of peripheral blood mononuclear cells (PBMC) from patients with ovarian cancer (FAPESP 2006/04900-2). The current project proposes to evaluate the receptor repertoire (inhibitory receptors: KIR2DL1, KIR2DL2/3 and KIR3DL1 and activating receptors: NKp30, NKp44, NKp46, NKG2D and DNAM-1) and functional integrity (CD107a molecule expression and cytotoxicity against primary neoplasm cells) of the NK and NKT-like lymphocytes from patients with ovarian neoplasm, before and after the ex vivo expansion of CD56+ cells. The experimental design will allow the evaluation of effector cell subtypes independently, and to take into account the clinical stage of the subjects. (AU)
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