Advances in the study of the lateral parabrachial nucleus and rostral nucleus of solitary tract to control sodium palatability and hydromineral balance

• Grant number: 12/01955-1
• Support Opportunities: Regular Research Grants
• Start date: May 01, 2012
• End date: April 30, 2015
• Field of knowledge: Biological Sciences - Physiology - Physiology of Organs and Systems
• Principal Investigator: Carina Aparecida Fabrício de Andrade
• Grantee: Carina Aparecida Fabrício de Andrade
• Host Institution: Faculdade de Odontologia (FOAr). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
• Associated researchers: José Vanderlei Menani ; Patricia Maria de Paula

Abstract

The rostral portion of the nucleus of the solitary tract (rNTS), located in the medulla oblongata, is considered the first synaptic relay for integration of sodium taste sensorial information. The rNTS receives and send projections to different forebrain and hindbrain areas related to hydroeletrolitic balance control, including the lateral parabrachial nucleus (LPBN) in the pons. Besides the importance of the inhibitory mechanisms that control NaCl intake, the LPBN is also involved with cardiovascular regulation and sensorial gustatory information integration. However, is still not known if there is an interaction between the LPBN mechanisms to control sodium intake; if these LPBN mechanisms interfere with sodium palatability and cardiovascular regulation; or if the inhibition of rNTS changes sodium intake and palatability. Therefore, the aims of the present study are: a) to investigate a possible interaction between the LPBN adrenergic and purinergic mechanisms to control 0.3 M NaCl and water intake; b) to study if the activation and/or blockage of LPBN serotonergic mechanism would change palatability (taste reactivity) to 0.3 M NaCl in dehydrated animals; c) to study the role of rNTS on water and 0.3 M NaCl intake and palatability; d) to investigate the effects of activation and/or blockage of LPBN serotonergic mechanism on blood pressure recovery after hypotensive blood loss. Thus, male Holtzman rats with stainless steel cannulas implanted bilaterally into the LPBN or rNTS will be submitted to protocols to measure water and sodium intake and taste reactivity test to sodium solution, while in rats with LPBN canullas will also be measured blood pressure after hypotensive blood loss. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

C.A.F. ANDRADE; G.M.F. ANDRADE-FRANZÉ; P.M. DE PAULA; L.A. DE LUCA JR.; J.V. MENANI. Role of α2-adrenoceptors in the lateral parabrachial nucleus in the control of body fluid homeostasis. Brazilian Journal of Medical and Biological Research, v. 47, n. 1, p. 11-18, 2014-01-10. (12/01955-1)

ANDRADE, C. A. F.; DE OLIVEIRA, L. B.; ANDRADE-FRANZE, G. M. F.; DE LUCA, JR., L. A.; COLOMBARI, DEBORA S. A.; MENANI, J. V.. Gabaergic and opioid receptors mediate the facilitation of NaCl intake induced by alpha(2)-adrenergic activation in the lateral parabrachial nucleus. Behavioural Brain Research, v. 278, p. 535-541, FEB 1 2015. (12/01955-1)

ANDRADE, C. A. F.; ANDRADE-FRANZE, G. M. F.; DE PAULA, P. M.; DE LUCA, L. A., JR.; MENANI, J. V.. Role of alpha(2)-adrenoceptors in the lateral parabrachial nucleus in the control of body fluid homeostasis. Brazilian Journal of Medical and Biological Research, v. 47, n. 1, p. 8-pg., 2014-01-01. (12/01955-1)