Serine proteinase inhibitors in pulmonary cells and in emphysema
| Grant number: | 11/07001-7 |
| Support type: | Regular Research Grants |
| Duration: | May 01, 2012 - October 31, 2014 |
| Field of knowledge: | Biological Sciences - Biochemistry |
| Principal Investigator: | Sergio Daishi Sasaki |
| Grantee: | Sergio Daishi Sasaki |
| Home Institution: | Centro de Ciências Naturais e Humanas (CCNH). Universidade Federal do ABC (UFABC). Ministério da Educação (Brasil). Santo André , SP, Brazil |
Abstract
Chronic obstructive pulmonary disease (COPD) can be described as an assembly of pathological modifications, since chronic inflammation up to pulmonary tissue degradation caused by proteinases. At the present moment there are not specific medicines to treat the disease. The most commonly problems in COPD are chronic bronchitis and emphysema, which are the main causes of mortality in adults and elder people. The metalloproteinases and serine proteinases, specifically human neutrophil elastase, are involved in the first steps of disease development. Despite of treatments used to avoid the advance of its disease to more serious stages, its considered irreversible yet, and generally it takes to development of others cardio respiratory problems and to death. Serine proteinase inhibitors are considered as one possible alternative treatment against emphysema to avoid the development of disease, although there is not any definitive therapy using these molecules until now. In this work we propose to investigate the potential of the serine proteinases inhibitors rBmTI-A and rBmTI-6 as protective molecules against lung emphysema development in mice model, additionally we will verify the production of serine proteinases in this model by activities assays and microarray. (AU)