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Assessment of folate status after mandatory folic acid fortification and health consequences: population-based study in the City of São Paulo


Much attention has been paid to the folate because of its role as nutrients that are key for the maintenance of good health and prevention of diseases. In addition to its already established role in reducing the incidence of neural tube defects, folate and vitamins B6 and B12 are metabolically related to homocysteine (hcy), in turn, are considered a risk factor for adverse events such as dementia, Alzheimer's disease, bone fractures, cancers and, especially cardiovascular diseases. Brazil and other countries have adopted public policies by which folate fortification of certain foods is mandatory for preventing and combating vitamin deficiency. The results of studies are conflicting in the assessment of dietary intake of folate and folic acid and their corresponding levels and hcy concentration. The lack of accurate methods for measuring dietary intake is possibly the reason for the no association between food intake and chronic diseases or even the lack of relationship between nutrient intake and their respective biomarker. Data will be obtained from population-based study in São Paulo-Brazil, who used two 24-hour dietary recall to assess dietary intake and collected blood sample. This project proposes: 1) the develop and apply of statistical methodology for the study of association between the habitual intake of nutrients involved, directly or indirectly, in hcy metabolism and 2) to assess the dietary intake and blood levels of folate, hcy and unmetabolized folic acid after mandatory folic acid fortification, considering the genetic variants involved in metabolism. (AU)

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Scientific publications (5)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
STELUTI, JOSIANE; CARVALHO, ALINE M.; CARIOCA, ANTONIO A. F.; MIRANDA, ANDREIA; GATTAS, GILKA J. F.; FISBERG, REGINA M.; MARCHIONI, DIRCE M.. Genetic Variants Involved in One-Carbon Metabolism: Polymorphism Frequencies and Differences in Homocysteine Concentrations in the Folic Acid Fortification Era. NUTRIENTS, v. 9, n. 6, . (11/19788-1, 12/05505-0, 10/19899-5)
STELUTI, JOSIANE; REGINALDO, CHRISTINA; SELHUB, JACOB; PAUL, LIGI; FISBERG, REGINA MARA; MARCHIONI, DIRCE MARIA. Presence of circulating folic acid in plasma and its relation with dietary intake, vitamin B complex concentrations and genetic variants. EUROPEAN JOURNAL OF NUTRITION, v. 58, n. 8, p. 3069-3077, . (11/19788-1, 15/12196-2, 12/05505-0, 10/19899-5)
STELUTI, JOSIANE; PALCHETTI, CECILIA ZANIN; MIRANDA, ANDREIA MACHADO; FISBERG, REGINA MARA; MARCHIONI, DIRCE MARIA. DNA methylation and one-carbon metabolism related nutrients and polymorphisms: analysis after mandatory flour fortification with folic acid. BRITISH JOURNAL OF NUTRITION, v. 123, n. 1, p. 23-29, . (11/19788-1, 12/05505-0, 10/19899-5, 15/12196-2)
STELUTI, JOSIANE; MIRANDA, ANDREIA MACHADO; DE CARLI, EDUARDO; PALCHETTI, CECILIA ZANIN; FISBERG, REGINA MARA; LOBO MARCHIONI, DIRCE MARIA. Unmetabolized folic acid is associated with TNF-alpha, IL-1 beta and IL-12 concentrations in a population exposed to mandatory food fortification with folic acid: a cross-sectional population-based study in Sao Paulo, Brazil. EUROPEAN JOURNAL OF NUTRITION, v. 60, n. 2, . (10/19899-5, 12/05505-0, 11/19788-1, 15/12196-2)
VERLY-, JR., ELISEU; STELUTI, JOSIANE; FISBERG, REGINA MARA; MARCHIONI, DIRCE MARIA LOBO. A Quantile Regression Approach Can Reveal the Effect of Fruit and Vegetable Consumption on Plasma Homocysteine Levels. PLoS One, v. 9, n. 11, . (11/19788-1, 10/19899-5, 09/15831-0)

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