Advanced search
Start date
Betweenand

Exposure to ambient and occupational pollution in uterus and its repercussion on development of allergic lung inflammation in offspring: correlation with epigenetic mechanisms

Abstract

The ambient and occupational pollution has been object of study for many researchers due its serious implications on the public health. The Formaldehyde (FA) is a chemical agent widely used a lot of industries, laboratories of anatomy, pathology, histology, emitted for the fuel burning, and also it is expelled in the smoke of the cigarette, which is characterized by ambient and occupational pollutant. The FA is an irritating of the airways and inductor of asthma; still he has a potential carcinogenic effect. The morbity and the mortality of the asthma have been correlated with the exposition of individuals the ambient and occupational pollutants as the FA. In this context, my scientific studies have been focused in the harmful effect of FA on the pulmonary tissue. Data of literature has shown to the correlation of the exposition the atmosphere pollutants during the pregnancy as factor of risk for trigger of pulmonary disease in adult phase. On the basis of this observation and in my subject of research, the study of the association of the exposition to the FA during the gestation and the consequences of this for the inflammation development will be the subject of study of this project. Correlation with epigenetic mechanisms will be studied. Specifically, this project will investigate if the intrauterine FA exposure modulates parameters of immune response which are responsible of the innate and acquired inflammation in the young animais. Our studies will prioritize the analysis of cells recruited in the lung, blood and bone marrow, co-stimulators molecule expression CD40, CD80 and CD86 and MHC of classroom I, production of anaphylactic antibodies, release and gene expression of inflammatory and antiinflamatory cytokines, airways reactivity and DNA methylation status. Additionally, biomarkers of carcinogenicity, mutagenicity and oxidative stress will be quantified in maternal tissue, in the attempt to correlate them it and to characterize the poisoning intensity maternal. This project was conceived considering that the inquiry of the molecular mechanisms of the effect caused for the ambient and occupational poisoning is, today, a fact essential to explain the data unquestioned epidemiologists of the actual damages for the pollution to the health human being. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
Articles published in other media outlets (0 total):
More itemsLess items
VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Scientific publications (5)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
IBRAHIM, BEATRIZ SILVA; BARIONI, ERIC DIEGO; HELUANY, CINTIA; BRAGA, TARCIO TEODORO; DREWES, CARINE CRISTIANE; COSTA, SILVIA GOES; SARAIVA CAMARA, NIELS OLSEN; POLISELLI FARSKY, SANDRA HELENA; LINO-DOS-SANTOS-FRANCO, ADRIANA. Beneficial effects of vitamin C treatment on pregnant rats exposed to formaldehyde: Reversal of immunosuppression in the offspring. Toxicology and Applied Pharmacology, v. 300, p. 77-81, JUN 1 2016. Web of Science Citations: 5.
MAIELLARO, MARILIA; MACEDO, RODRIGO SILVA; MENDES, EDUARDO; TAVARES-DE-LIMA, WOTHAN; FERREIRA, CAROLINE MARCANTONIO; LINO-DOS-SANTOS-FRANCO, ADRIANA. High dose of formaldehyde exposure during pregnancy increases neutrophils lung influx evoked by ovalbumin in the offspring. Inflammation Research, v. 65, n. 3, p. 179-181, MAR 2016. Web of Science Citations: 2.
DA SILVA, CRISTIANE MIRANDA; LEAL, MAYARA PERES; BROCHETTI, ROBSON ALEXANDRE; BRAGA, TARCIO; VITORETTI, LUANA BEATRIZ; SARAIVA CAMARA, NIELS OLSEN; DAMAZO, AMILCAR SABINO; LIGEIRO-DE-OLIVEIRA, ANA PAULA; CHAVANTES, MARIA CRISTINA; LINO-DOS-SANTOS-FRANCO, ADRIANA. Low Level Laser Therapy Reduces the Development of Lung Inflammation Induced by Formaldehyde Exposure. PLoS One, v. 10, n. 11 NOV 16 2015. Web of Science Citations: 19.
MAIELLARO, MARILIA; CORREA-COSTA, MATHEUS; VITORETTI, LUANA BEATRIZ; GIMENES JUNIOR, JOAO ANTONIO; SARAIVA CAMARA, NIELS OLSEN; TAVARES-DE-LIMA, WOTHAN; POLISELLI FARSKY, SANDRA HELENA; LINO-DOS-SANTOS-FRANCO, ADRIANA. Exposure to low doses of formaldehyde during pregnancy suppresses the development of allergic lung inflammation in offspring. Toxicology and Applied Pharmacology, v. 278, n. 3, p. 266-274, AUG 1 2014. Web of Science Citations: 18.
LINO-DOS-SANTOS-FRANCO, ADRIANA; AMEMIYA, RENATA MIDORI; LIGEIRO DE OLIVEIRA, ANA PAULA; DAMAZO, AMILCAR SABINO; BREITHAUPT-FALOPPA, ANA CRISTINA; VITORETTI, LUANA BEATRIZ; ACCETURI, BEATRIZ GOLEGA; TAVARES-DE-LIMA, WOTHAN. The putative role of ovary removal and progesterone when considering the effect of formaldehyde exposure on lung inflammation induced by ovalbumin. Clinics, v. 68, n. 12, p. 1528-1536, 2013. Web of Science Citations: 3.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.