Formaldehyde (FA) is a chemical agent widely used in health and in the production of materials. The FA is an irritant of airways, eyes and is a potent inducer of inflammatory lung diseases such as asthma. Moreover, FA causes carcinogenic effects.The literature has shown the correlation between exposure to environmental pollutants during pregnancy as a risk factor for onset of lung disease in young or adult sphase, however the mechanisms involved are unclear. In addition, studies show that some pollutants play an important immunosuppressive effects causing increased susceptibility of infections reducing function of neutrophils, macrophages and natural killer.The mechanisms underlying the acute lung inflammation caused by a systemic infection can be investigated experimentally by the administration of LPS systemically to laboratory animals. This model develops lung injury mainly characterized by neutrophil infiltration which is enhanced by several cytokines such as IL-1², IL-8, and TNF-± and LPS also causes bronchial hyperreactivity.Based on the above it is reasonable to assume that intrauterine exposure to pollutants such as FA may exert effects on the immune response of the offspring by altering functions in cells of the innate immune system, impairing the body's defense by infections. Thus, studies to evaluate these possible changes are relevant.
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