Pharmacology, toxicology and chemistry of the oil extracted from fatty bodies of the Rana catesbeiana Shaw

• Grant number: 04/02466-8
• Support Opportunities: Research Grants - Innovative Research in Small Business - PIPE
• Start date: October 01, 2004
• End date: June 30, 2007
• Field of knowledge: Biological Sciences - Pharmacology - Ethnopharmacology
• Principal Investigator: Jayme Antônio Aboin Sertié
• Grantee: Jayme Antônio Aboin Sertié
• Company: Central Brasileira de Comercialização e Distribuição de Rã Ltda

Abstract

The popular use of the oil extracted from the fatty body of the Rana catesbeiana Shaw frog has increased, above all as an anti-inflammatory anti-ulcerant gastro-duodenal cicatrizant. These bodies, the oil of which is very simple to extract, are a waste material in abattoirs, therefore their cost is zero. The incidence of the pathologies mentioned has grown at an average 10 per cent a year and, amongst the most widely sold medicines to combat them, anti-inflammatory anti-ulcerants account for 31 per cent of the world market. In addition to being expensive, the available medicines have some limitations in clinical use and certain precautions need to be exercised in their administration. Since the scientific literature makes no reference to studies in this area, the present project proposes to carry out a pharmacological, toxicological, and chemical screening, involving the evaluation of the anti-inflammatory activity of the oil from that Rana catesbeiana Shaw frog species applied topically and administered orally. The data obtained will be compared to that of standard drugs in four experimental models, two severe and two sub-chronic, determining the dose-effect relationship and calculating the effective dose. It is also intended to evaluate the anti gastric ulcer effect, compared to standard drugs, in two rigorous experimental models, determining the index of lesions, the parameters of gastric secretion and the establishment of the effective dose, amongst various other activities. The project also includes, at the end of this phase, the chemical-analytical characterization and standardization of the initial sample to be evaluated. (AU)