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Evaluation of the acute toxicity of hydrophobic dyes using passive dosing

Grant number: 19/24976-3
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): August 01, 2020
Effective date (End): July 31, 2021
Field of knowledge:Biological Sciences - Pharmacology - Toxicology
Principal researcher:Gisela de Aragão Umbuzeiro
Grantee:Matheus Henrique de Oliveira
Home Institution: Faculdade de Tecnologia (FT). Universidade Estadual de Campinas (UNICAMP). Limeira , SP, Brazil


Dyes have been largely used by the industrial sector, especially in the textile industry. The dyes that are not attached to the fibers can be discharged in water bodies via effluent, which may impact the water quality due to their toxic properties. Disperse dyes are among the most used dyes in the textile sector, and because of their hydrophobic properties, they are poorly soluble in water. Passive dosing has emerged recently as a route of exposure employed in toxicity tests that allows working with poorly soluble compounds by using a polymer, which can maintain more constant and stable concentrations of the compound in the medium test via partitioning equilibrium. Thus, the present project aims to test the acute toxicity of hydrophobic dyes via passive dosing with aquatic organisms. Such dyes will be chosen from Max Weaver Dye Library (MWDL) repository, a database with 98,000 dyes samples at North Carolina State University. They will be selected based on their octanol/water partition coeficient (log Kow) and tested only after their purity and chemical structure are confirmed. It is expected to better understand the toxicity of the dyes chosen using a methodology that compensates for losses that commonly occur over toxicity assays with hydrophobic compounds, as well as contribute with more data on dyes toxicity. (AU)

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