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Martin Georg Peter | University of Potsdam - Germany

Grant number: 08/01663-5
Support type:Research Grants - Visiting Researcher Grant - International
Duration: August 29, 2008 - July 31, 2009
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal Investigator:Marcos Nogueira Eberlin
Grantee:Marcos Nogueira Eberlin
Visiting researcher: Martin Georg Peter
Visiting researcher institution: University of Potsdam, Germany
Home Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil


AGO's which are derived from partially N-acetylated poly-glucosamine (i.e. chitosan) have attracted much interest to their biological activities, mainly being involved in signaling pathways, such as morphogenetic action in embryo development in animals and regulation of the synthesis of extracellular matrix in chondrocytes. An AGO hexamer of the composition (GlcNAc)3(GlcN)3 can occur principally in form of 20 isomers. Neither the sequence analysis by NMR spectroscopy, nor chemical synthesis of higher AGO's, such as hexamers, has not yet been achieved. Our aim is to analyze AGO's which are isolated from hydrolysates of chitosan by most advanced mass spectrometry. Besides the elucidation of sequences of the individual isomeric components present in complex mixtures, we will investigate the limits of the methodology with respect to the length of an oligosaccharide and the complexity of the mixture. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
VIJAYAKRISHNAN‚ B.; ISSAREE‚ A.; CORILO‚ Y.E.; FERREIRA‚ C.R.; EBERLIN‚ M.N.; PETER‚ M.G. MSn of the six isomers of (GlcN)2(GlcNAc)2 aminoglucan tetrasaccharides (diacetylchitotetraoses): Rules of fragmentation for the sodiated molecules and application to sequence analysis of hetero-chitooligosaccharides. Carbohydrate Polymers, v. 84, n. 2, p. 713-726, 2011.

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