Study of biological material by vibrational spectroscopy and X-ray fluorescence

• Grant number: 11/21374-0
• Support Opportunities: Research Grants - Visiting Researcher Grant - International
• Start date: February 06, 2012
• End date: March 05, 2012
• Field of knowledge: Engineering - Biomedical Engineering
• Principal Investigator: Airton Abrahao Martin
• Grantee: Airton Abrahao Martin
• Visiting researcher: Sergei Kazarian
• Visiting researcher institution: Imperial College London, England
• Host Institution: Instituto de Pesquisa e Desenvolvimento (IP&D). Universidade do Vale do Paraíba (UNIVAP). São José dos Campos , SP, Brazil

Abstract

This project is supported by CNPq and FAPESP involving three research fronts: The optical study and diagnosis of different types of human tissues and fluids, confocal Raman study on human skin and finally application of fluorescence X-rays in dentistry. The main goal of the first line of research is to use the knowledge obtained in our previus study of cancers by the technique of FT-Raman spectroscopy in order to facilitate the in vivo optical diagnosis of cancer noninvasively (or minimally invasive), as well as other human diseases and that provides results in real time. At this stage of the project, we use a dispersive Raman (Princeton) coupled to two different lasers of 785 and 830 nm, the FT-Raman system with 1064 nm, confocal Raman system with 785 and 671 nm and the system of infrared imaging spectroscopy (FT -IR) Spotlight 400. In the second line of research, we studied by confocal Raman spectroscopy in vivo biochemical composition of human skin by different age groups and in different layers. Finally, the last line of research approach the study of changes in organic and inorganic components of human dentin after the use of laser irradiation of Er: YAG laser with low energy densities. (AU)