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Bed nucleus of the stria terminalis noradrenergic system modulates contextual fear conditionig: possible interaction with CRF and glutamatergic and nitrergic neurotransmission

Grant number: 12/09300-4
Support type:Regular Research Grants
Duration: August 01, 2012 - July 31, 2014
Field of knowledge:Biological Sciences - Pharmacology
Principal Investigator:Leonardo Resstel Barbosa Moraes
Grantee:Leonardo Resstel Barbosa Moraes
Home Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

The bed nucleus of the stria terminalis (BNST) seems to be critically involved with expression of anxiety-related responses. The BNST is one of the main targets of noradrenergic innervation in the central nervous system. Moreover, some evidence showed that during aversive situations noradrenaline releases is increased in BNST. Previous studies from our laboratory showed that BNST noradrenergic neurotransmission is involved with conditioned emotional response (CER) by activation of both ±1 and ²1-adrenergic receptors. In addition, previous studies described that BNST ²1-adrenergic receptors activation increases the local release of glutamate. Moreover, this glutamate releases is dependent of CRF1 receptors. In fact, there is evidence for the involvement of BNST in stress responses mediated by CRF and the anxiogenic-like effects of CRF in BNST are mediated by CRF1 receptors. Therefore, the modulation of CER by the BNST noradrenergic system could involve the participation of other neurotransmitters; however, this possibility was not tested in BNST for contextual fear conditioning (CFC). Therefore, we believe that the BNST noradrenergic system interacts with other mediators present in BNST on the modulation of CFC. To test this hypothesis, we will have the pharmacological manipulation of CRF1 receptors, glutamate and nitrergic system. (AU)

Scientific publications (12)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FOGACA, MANOELA V.; CAMPOS, ALLINE C.; COELHO, LUDMILA D.; DUMAN, RONALD S.; GUIMARAES, FRANCISCO S. The anxiolytic effects of cannabidiol in chronically stressed mice are mediated by the endocannabinoid system: Role of neurogenesis and dendritic remodeling. Neuropharmacology, v. 135, p. 22-33, JUN 2018. Web of Science Citations: 20.
FOGACA, M. V.; FEDOCE, A. G.; FERREIRA-JUNIOR, N. C.; GUIMARES, F. S.; RESSTEL, L. B. Involvement of M1 and CB1 receptors in the anxiogenic-like effects induced by neostigmine injected into the rat prelimbic medial prefrontal cortex. Psychopharmacology, v. 233, n. 8, p. 1377-1385, APR 2016. Web of Science Citations: 4.
FEDOCE, A. G.; FERREIRA-JUNIOR, N. C.; REIS, D. G.; CORREA, F. M. A.; RESSTEL, L. B. M. M-3 muscarinic receptor in the ventral medial prefrontal cortex modulating the expression of contextual fear conditioning in rats. Psychopharmacology, v. 233, n. 2, p. 267-280, JAN 2016. Web of Science Citations: 5.
FASSINI, ALINE; ANTERO, LEANDRO S.; CORREA, FERNANDO M. A.; JOCA, SAMIA R.; RESSTEL, LEONARDO B. M. The Prelimbic Cortex Muscarinic M-3 Receptor-Nitric Oxide-Guanylyl Cyclase Pathway Modulates Cardiovascular Responses in Rats. Journal of Neuroscience Research, v. 93, n. 5, p. 830-838, MAY 2015. Web of Science Citations: 6.
FASSINI, ALINE; SCOPINHO, AMERICA A.; RESSTEL, LEONARDO B. M.; CORREA, FERNANDO M. A. kappa-Opioid receptors in the infralimbic cortex modulate the cardiovascular responses to acute stress. Experimental Physiology, v. 100, n. 4, p. 377-387, APR 2015. Web of Science Citations: 4.
FABRI, DENISE R. S.; HOTT, SARA C.; REIS, DANIEL G.; BIOJONE, CAROLINE; CORREA, FERNANDO M. A.; RESSTEL, LEONARDO B. M. The expression of contextual fear conditioning involves activation of a NMDA receptor-nitric oxide-cGMP pathway in the dorsal hippocampus of rats. European Neuropsychopharmacology, v. 24, n. 10, p. 1676-1686, OCT 2014. Web of Science Citations: 13.
FASSINI, ALINE; SCOPINHO, AMERICA A.; RESSTEL, LEONARDO B. M.; CORREA, FERNANDO M. A. Opioid receptors in the prelimbic cortex modulate restraint stress-induced cardiovascular responses in the rat. Neuropharmacology, v. 85, p. 367-374, OCT 2014. Web of Science Citations: 6.
AGUIAR, DANIELE C.; HOTT, SARA C.; DEOLINDO, MILENA V.; GUIMARAES, FRANCISCO S.; RESSTEL, LEONARDO B. M. The dorsolateral periaqueductal grey N-methyl-D-aspartate/nitric oxide/cyclic guanosine monophosphate pathway modulates the expression of contextual fear conditioning in rats. JOURNAL OF PSYCHOPHARMACOLOGY, v. 28, n. 5, p. 479-485, MAY 2014. Web of Science Citations: 7.
MORAES-NETO, T. B.; SCOPINHO, A. A.; BIOJONE, C.; CORREA, F. M. A.; RESSTEL, L. B. M. INVOLVEMENT OF DORSAL HIPPOCAMPUS GLUTAMATERGIC AND NITRERGIC NEUROTRANSMISSION IN AUTONOMIC RESPONSES EVOKED BY ACUTE RESTRAINT STRESS IN RATS. Neuroscience, v. 258, p. 364-373, JAN 31 2014. Web of Science Citations: 17.
SCOPINHO, AMERICA A.; LISBOA, SABRINA F. S.; GUIMARAES, FRANCISCO S.; CORREA, FERNANDO M. A.; RESSTEL, LEONARDO B. M.; JOCA, SAMIA R. L. Dorsal and Ventral Hippocampus Modulate Autonomic Responses but Not Behavioral Consequences Associated to Acute Restraint Stress in Rats. PLoS One, v. 8, n. 10 OCT 17 2013. Web of Science Citations: 13.
ALVES, FERNANDO H. F.; GOMES, FELIPE V.; REIS, DANIEL G.; CRESTANI, CARLOS C.; CORREA, FERNANDO M. A.; GUIMARAES, FRANCISCO S.; RESSTEL, LEONARDO B. M. Involvement of the insular cortex in the consolidation and expression of contextual fear conditioning. European Journal of Neuroscience, v. 38, n. 2, p. 2300-2307, JUL 2013. Web of Science Citations: 13.
BORELLI, KARINA G.; ALBRECHET-SOUZA, LUCAS; FEDOCE, ALESSANDRA G.; FABRI, DENISE S.; RESSTEL, LEONARDO B.; BRANDAO, MARCUS L. Conditioned fear is modulated by CRF mechanisms in the periaqueductal gray columns. Hormones and Behavior, v. 63, n. 5, p. 791-799, MAY 2013. Web of Science Citations: 8.

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