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Comparative study on the effects of sildenafil and tadalafil in advanced pulmonary arterial hypertension associated with congenital heart defects (Eisenmenger syndrome)

Grant number: 12/10739-0
Support type:Regular Research Grants
Duration: September 01, 2012 - August 31, 2014
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Antonio Augusto Barbosa Lopes
Grantee:Antonio Augusto Barbosa Lopes
Home Institution: Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil


Sildenafil (20 mg t.i.d.) and tadalafil (40 mg, single daily dose) are oral therapies approved for pulmonary arterial hypertension (PAH). Because there are no comparative studies using these drugs, the present study is aimed at comparing their effects in subjects with PAH associated with congenital heart disease (so called Eisenmenger syndrome). The study will be randomized, and performed over six months. The impact of treatments on the physical capacity will be tested by the six-minute walk test, and pulse oxymetry. Health-related quality of life will be analyzed as well. The possible impact of both phosphodiesterase-5 inhibitors on endothelial and platelet dysfunction will be analyzed by measuring the circulating levels of von Willebrand fact, tissue-type plasminogen activator, Thrombomodulin, P-selectin, beta-thromboglobulin and soluble CD40-L. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CLAVE, MARIANA M.; MAEDA, NAIR Y.; THOMAZ, ANA M.; BYDLOWSKI, SERGIO P.; LOPES, ANTONIO A. Phosphodiesterase type 5 inhibitors improve microvascular dysfunction markers in pulmonary arterial hypertension associated with congenital heart disease. CONGENITAL HEART DISEASE, v. 14, n. 2, p. 246-255, MAR-APR 2019. Web of Science Citations: 2.
CLAVE, MARIANA M.; MAEDA, NAIR Y.; CASTRO, CLAUDIA R. P.; BYDLOWSKI, SERGIO P.; LOPES, ANTONIO A. Factors influencing outcomes in patients with Eisenmenger syndrome: a nine-year follow-up study. PULMONARY CIRCULATION, v. 7, n. 3, p. 635-642, JUL-SEP 2017. Web of Science Citations: 4.

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