Comparative study of the repair process using autogenous bone and beta-tricalcium phosphate in human sinus floor augmentation: tomographical, histological, histometrical and imunohistochemical evaluation

• Grant number: 12/10028-7
• Support Opportunities: Regular Research Grants
• Start date: September 01, 2012
• End date: August 31, 2014
• Field of knowledge: Health Sciences - Dentistry - Oral and Maxillofacial Surgery
• Principal Investigator: Eduardo Hochuli Vieira
• Grantee: Eduardo Hochuli Vieira
• Host Institution: Faculdade de Odontologia (FOA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil
• City of the host institution: Araçatuba
• Associated researchers: Idelmo Rangel Garcia Junior ; Roberta Okamoto

Abstract

Bone resorption and pneumatization of the maxillary sinus after the teeth loss in the posterior maxilla, associated with low bone density in this region, offers inappropriate region for the installation of dental implants. The correction of bone defects is the restoration of structures lost and can be replaced by alloplastic implants or bone grafting. The autogenous bone is considered the "gold standard" in bone grafts because of its osteogenic, osteoconductive and osteoinductive properties. However, it has disadvantages such as morbidity at the donor site, possibility of vascular-nerve injury, the unpredictable resorption and increased surgical time. As a result, much of the research seeks to develop materials, alloplastic or not, able to replace bone in reconstructions, overcoming the limitations of autografts. Beta-Tricalcium Phosphate (Chronos ® - Synthes - Rio Claro / SP) is a synthetic bone substitute, biocompatible, osteoconductive, available in the form of granules which can be used in augmentation of maxillary sinus. This study aims to compare the healing process using autogenous bone, autogenous bone associated with beta-tricalcium phosphate and beta-tricalcium phosphate only in maxillary sinus augmentation in humans using tomographic, histological, histometric, and immunohistochemistry analysis. (AU)

Scientific publications

(4)

(The scientific publications listed on this page originate from the Web of Science or SciELO databases. Their authors have cited FAPESP grant or fellowship project numbers awarded to Principal Investigators or Fellowship Recipients, whether or not they are among the authors. This information is collected automatically and retrieved directly from those bibliometric databases.)

PEREIRA, R. S.; GORLA, L. F.; BOOS, F. B. J. D.; OKAMOTO, R.; GARCIA JUNIOR, I. R.; HOCHULI-VIEIRA, E.. Use of autogenous bone and beta-tricalcium phosphate in maxillary sinus lifting: histomorphometric study and immunohi'stochemical assessment of RUNX2 and VEGF. International Journal of Oral and Maxillofacial Surgery, v. 46, n. 4, p. 503-510, APR 2017. (12/08455-4, 12/10028-7)

PEREIRA, RODRIGO DOS SANTOS; JORGE DAURA BOOS, FERNANDA BRASIL; GORLA, LUIS FERNADO; GARCIA, JR., IDELMO RANGEL; OKAMOTO, ROBERTA; HOCHULI-VIEIRA, EDUARDO. Maxillary Sinus Elevation Surgery with ChronOS and Autogenous Bone Graft: Immunohistochemical Assessment of RUNX2, VEGF, TRAP, and Osteocalcin. INTERNATIONAL JOURNAL OF PERIODONTICS & RESTORATIVE DENTISTRY, v. 37, n. 6, p. E321-E327, NOV-DEC 2017. (12/10028-7, 12/08455-4)

BONARDI, JOAO PAULO; PEREIRA, RODRIGO DOS SANTOS; JORGE BOOS LIMA, FERNANDA BRASIL DAURA; FAVERANI, LEONARDO PEREZ; GRIZA, GERALDO LUIZ; OKAMOTO, ROBERTA; HOCHULI-VIEIRA, EDUARDO. Prospective and Randomized Evaluation of ChronOS and Bio-Oss in Human Maxillary Sinuses: Histomorphometric and Immunohistochemical Assignment for Runx2, Vascular Endothelial Growth Factor, and Osteocalcin. JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, v. 76, n. 2, p. 325-335, FEB 2018. (12/10028-7, 12/08455-4)

PEREIRA, RODRIGO DOS SANTOS; JORGE DAURA BOOS, FERNANDA BRASIL; DO GORLA, LUIS FERNA; GARCIA, JR., DELMO RANGE; OKAMOTO, ROBERTA; HOCHULI-VIEIRA, EDUARDO. Maxillary Sinus Elevation Surgery with ChronOS and Autogenous Bone Graft: Analysis of Histometric and Volumetric Changes. INTERNATIONAL JOURNAL OF PERIODONTICS & RESTORATIVE DENTISTRY, v. 36, n. 6, p. 885-892, NOV-DEC 2016. (12/08455-4, 12/10028-7)