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Tomografic, Histologic, Histometric and imunohistochemistry analyses of beta tricalcium phosphate and autogenous bone mixture in sinus floor augmentation

Grant number: 12/08455-4
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): November 01, 2012
Effective date (End): February 28, 2014
Field of knowledge:Health Sciences - Dentistry - Oral and Maxillofacial Surgery
Principal Investigator:Eduardo Hochuli Vieira
Grantee:Rodrigo dos Santos Pereira
Host Institution: Faculdade de Odontologia (FOA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil


Inadequate bone height in posterior maxilla doesn't make oral rehabilitation with osseointegrated implants easy. Literature considered, autologous bone graft as gold standard, in maxillofacial reconstructions. However, the fact of a second surgery as well as use of general anesthesia, could be seem negatively in some cases. Autogenous bone graft disadvantages as donor site morbidity, unpredictable reasorption, among other are known, making bone substitutes use, as a good option for posterior maxilar reconstruction. Bone substitutes can be allografts, xenografts and alloplastic materials. These materials can highlight the beta tricalcium phosphate (²-TCP), which is an alloplastic mateterial used like bone substitute since the 70s.The aim of this study is to evaluate autogenous bone graft mixed with ²-TCP in human maxillary sinus lifiting by tomografic, histometric, immunohistochemical and histologic analysis. Autogenous bone will be collected, by thephine drill, with 10 mm diameter in retromolar region and crushed. After that, fifty percent of ²-TCP (Chronos - Synthes®) will be added. Sinus lifting surgery will be approached by lateral wall, proposed by Tatum. After 6 months, biopsy will be taken by trephine burr (2.5 mm Neodent®) before implants placement. (AU)

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Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BONARDI, JOAO PAULO; PEREIRA, RODRIGO DOS SANTOS; JORGE BOOS LIMA, FERNANDA BRASIL DAURA; FAVERANI, LEONARDO PEREZ; GRIZA, GERALDO LUIZ; OKAMOTO, ROBERTA; HOCHULI-VIEIRA, EDUARDO. Prospective and Randomized Evaluation of ChronOS and Bio-Oss in Human Maxillary Sinuses: Histomorphometric and Immunohistochemical Assignment for Runx2, Vascular Endothelial Growth Factor, and Osteocalcin. JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, v. 76, n. 2, p. 325-335, . (12/10028-7, 12/08455-4)
PEREIRA, RODRIGO DOS SANTOS; JORGE DAURA BOOS, FERNANDA BRASIL; DO GORLA, LUIS FERNA; GARCIA, JR., DELMO RANGE; OKAMOTO, ROBERTA; HOCHULI-VIEIRA, EDUARDO. Maxillary Sinus Elevation Surgery with ChronOS and Autogenous Bone Graft: Analysis of Histometric and Volumetric Changes. INTERNATIONAL JOURNAL OF PERIODONTICS & RESTORATIVE DENTISTRY, v. 36, n. 6, p. 885-892, . (12/08455-4, 12/10028-7)
PEREIRA, R. S.; GORLA, L. F.; BOOS, F. B. J. D.; OKAMOTO, R.; GARCIA JUNIOR, I. R.; HOCHULI-VIEIRA, E.. Use of autogenous bone and beta-tricalcium phosphate in maxillary sinus lifting: histomorphometric study and immunohi'stochemical assessment of RUNX2 and VEGF. International Journal of Oral and Maxillofacial Surgery, v. 46, n. 4, p. 503-510, . (12/08455-4, 12/10028-7)
PEREIRA, RODRIGO DOS SANTOS; JORGE DAURA BOOS, FERNANDA BRASIL; GORLA, LUIS FERNADO; GARCIA, JR., IDELMO RANGEL; OKAMOTO, ROBERTA; HOCHULI-VIEIRA, EDUARDO. Maxillary Sinus Elevation Surgery with ChronOS and Autogenous Bone Graft: Immunohistochemical Assessment of RUNX2, VEGF, TRAP, and Osteocalcin. INTERNATIONAL JOURNAL OF PERIODONTICS & RESTORATIVE DENTISTRY, v. 37, n. 6, p. E321-E327, . (12/10028-7, 12/08455-4)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
PEREIRA, Rodrigo dos Santos. Análise tomográfica, histológica, histométrica e imunoistoquímica do beta tricálcio fosfato com osso autógeno em aumento do soalho de seio maxilar. 2014. Master's Dissertation - Universidade Estadual Paulista (Unesp). Faculdade de Odontologia. Araçatuba Araçatuba.

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