Heritability of Metabolic Phenotypes in the Brazilian Population

• Grant number: 12/12042-7
• Support Opportunities: Regular Research Grants
• Start date: October 01, 2012
• End date: March 31, 2015
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Alexandre da Costa Pereira
• Grantee: Alexandre da Costa Pereira
• Host Institution: Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
• Associated researchers: Ana Carolina de Mattos Zeri ; Gabriela Venturini da Silva ; José Eduardo Krieger

Abstract

Metabolomic analysis is the systematic analysis of metabolites in biological samples. The metabolic level of diverse substances can be used as valuable complement for understanding gene function and regulation, and can be used as quantitative phenotype for gene-mapping experiments. This type of analysis is being used in several biological specimens aiming at identifying biomarkers for several human conditions. NMR can be used to conduct a comprehensive analysis of a particular sample metabolite profile. This project aims at identifying different serum metabolites in human samples and establish the heritability values of these different compounds. In this proposal we will analyze the fasting serum of 1,500 individuals from a family-based study already conducted by our group. The metabolite profile will be established using NMR methods in collaboration with researches from the Laboratorio Nacional de Luz Sincontron and the statistic analysis will use a variance components method already mastered by our group and available in the SOLAR package. (AU)

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MALAGRINO, PAMELLA ARAUJO; VENTURINI, GABRIELA; YOGI, PATRICIA SCHNEIDER; DARIOLLI, RAFAEL; PADILHA, KALLYANDRA; KIERS, BIANCA; GOIS, TAMIRIS CARNEIRO; MORAIS CARDOZO, KARINA HELENA; CARVALHO, VALDEMIR MELECHCO; SALGUEIRO, JESSICA SILVA; et al. Proteome analysis of acute kidney injury - Discovery of new predominantly renal candidates for biomarker of kidney disease. JOURNAL OF PROTEOMICS, v. 151, n. SI, p. 66-73, JAN 16 2017. (12/05447-0, 13/13526-0, 13/17368-0, 12/12042-7, 11/04344-0)

DOMINGO-ALMENARA, XAVIER; BREZMES, JESUS; VENTURINI, GABRIELA; VIVO-TRUYOLS, GABRIEL; PERERA, ALEXANDRE; VINAIXA, MARIA. Baitmet, a computational approach for GC-MS library-driven metabolite profiling. METABOLOMICS, v. 13, n. 8, AUG 2017. (12/12042-7)

MALAGRINO, PAMELLA ARAUJO; VENTURINI, GABRIELA; YOGI, PATRICIA SCHNEIDER; DARIOLLI, RAFAEL; PADILHA, KALLYANDRA; KIERS, BIANCA; GOIS, TAMIRIS CARNEIRO; MORAIS CARDOZO, KARINA HELENA; CARVALHO, VALDEMIR MELECHCO; SALGUEIRO, JESSICA SILVA; et al. Proteome analysis of acute kidney injury - Discovery of new predominantly renal candidates for biomarker of kidney disease. JOURNAL OF PROTEOMICS, v. 151, p. 8-pg., 2017-01-16. (12/05447-0, 13/13526-0, 11/04344-0, 13/17368-0, 12/12042-7)

MALAGRINO, PAMELLA ARAUJO; VENTURINI, GABRIELA; YOGI, PATRICIA SCHNEIDER; DARIOLLI, RAFAEL; PADILHA, KALLYANDRA; KIERS, BIANCA; GOIS, TAMIRIS CARNEIRO; MOTTA-LEAL-FILHO, JOAQUIM MAURICIO; TAKIMURA, CELSO KIYOCHI; COSTA GIRARDI, ADRIANA CASTELLO; et al. Metabolomic characterization of renal ischemia and reperfusion in a swine model. Life Sciences, v. 156, p. 57-67, JUL 1 2016. (12/05447-0, 13/13526-0, 13/17368-0, 12/12042-7, 11/04344-0)

PADILHA, KALLYANDRA; VENTURINI, GABRIELA; PIRES, THIAGO DE FARIAS; HORIMOTO, ANDREA R. V. R.; MALAGRINO, PAMELLA ARAUJO; GOIS, TAMIRIS CARNEIRO; KIERS, BIANCA; OLIVEIRA, CAMILA MACIEL; ALVIM, RAFAEL DE OLIVEIRA; BLATT, CELSO; et al. Serum metabolomics profile of type 2 diabetes mellitus in a Brazilian rural population. METABOLOMICS, v. 12, n. 10, OCT 2016. (12/05447-0, 12/12042-7)