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Asthna coorte study: inflammatory and functional markers for astham control

Grant number: 12/11396-0
Support Opportunities:Regular Research Grants
Duration: October 01, 2012 - September 30, 2014
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal Investigator:Ana Luisa Godoy Fernandes
Grantee:Ana Luisa Godoy Fernandes
Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
Associated researchers:Ilka Lopes Santoro ; Lilian Ballini Caetano ; Maria Marta Ferreira Amorim


Achieving asthma control is the main goal of treatment by guidelines. The current control is to maintain patients without symptoms with normal lung function and low future risks of exacerbating, accelerate decline of lung function or side effects of maintenance medications. Method: Collection of clinical, inflammatory data and pulmonary function of asthmatics included in the 2006 protocol APITA. These patients are regularly seen at the outpatient clinic of the institution. They will be asked to fill the diary with asthma, and scheduling for collection of questionnaires (AQLQ, ACQ7), spirometry, induced sputum cytology and nasal lavage when asymptomatic. As outcome variables will be collected, the variation of the functional parameters over time (FEV1 mL / year), the frequency of moderate and severe exacerbations, inflammatory parameters, asthma control and quality of life questionnaires, and medication usage. Sample calculation: The cohort had 70 patients included, and it will be admitted a 20% lost follow up, therefore it will be necessary to evaluate 56 patients for analysis of results. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE FARIAS, CAMYLA F.; AMORIM, MARIA M. F.; DRACOULAKIS, MICHEL; CAETANO, LILIAN B.; SANTORO, ILKA L.; FERNANDES, ANA L. G.. Nasal lavage, blood or sputum: Which is best for phenotyping asthma?. Respirology, v. 22, n. 4, p. 671-677, . (12/11396-0, 15/21177-1)

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